Document Detail


Relation of femoral diameter, shear rate, and dilatory response to knee extensor exercise.
MedLine Citation:
PMID:  20308925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Younger women typically exhibit marked dilation of the common femoral artery (CFA) during knee extensor exercise; this is in apparent contrast to subject groups with larger (men) and/or older (older women) vessels, which on average display much smaller exercise-induced increases in CFA diameter. To gain additional insight into this variation, the present study closely examined within- and between-group relationships among CFA diameter, shear rate, and the magnitude of exercise-induced CFA dilation.
METHODS: Healthy women (15 younger and 18 older) and men (15 younger and 13 older) performed graded single-leg knee extensor exercise while CFA diameter and blood velocity were measured using Doppler ultrasound.
RESULTS: Resting CFA diameter was smaller (P < 0.05) in women (younger: 0.71 ± 0.02 cm; older: 0.72 ± 0.02 cm) compared with men (younger: 0.84 ± 0.01 cm; older: 0.97 ± 0.03 cm). Resting CFA diameter was inversely associated with peak shear rate (combined groups: r = -0.83, P < 0.001) and the magnitude of dilation in women (younger: r = -0.82; older: r = -0.73, P < 0.001) and younger men (r = -0.66, P < 0.01) but not in older men (r = -0.17, P = 0.56). The dilatory response of the CFA to graded increases in shear rate showed a continuum across groups best described by a quadratic function (r2 = 0.89). Using piecewise regression modeling, a threshold diameter of 0.79 cm was identified below which diameter is inversely related to the magnitude of CFA dilation but above which little to no dilation was present.
CONCLUSIONS: The CFA dilates to knee extensor exercise in women and men, the magnitude of which varies because of differences in shear rate across CFA diameters.
Authors:
Joaquin U Gonzales; Julie A Miedlar; Beth A Parker; David N Proctor
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  42     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-21     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1870-5     Citation Subset:  IM; S    
Affiliation:
Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Blood Flow Velocity / physiology
Exercise / physiology*
Female
Femoral Artery / physiology*,  ultrasonography
Humans
Knee / blood supply*,  physiology*,  ultrasonography
Male
Sex Factors
Shear Strength / physiology*
Vasodilation / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
M01 RR-10732/RR/NCRR NIH HHS; R01 AG018246/AG/NIA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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