Document Detail

Relation of Cag-A-positive Helicobacter pylori strain and some inflammatory markers in patients with ischemic heart diseases.
MedLine Citation:
PMID:  20726321     Owner:  NLM     Status:  MEDLINE    
Recently, a potential link between infectious agents and athero-sclerosis has been suggested. H. pylori strains bearing the cytotoxin associated gene A (Cag-A) provoked a heightened inflammatory response in vivo and showed stronger relation to gastric complication of this infection. The association between Cag-A positive strain and vascular diseases producing conflicting results. So, the present study aimed to estimate the seroprevalence of H. pylori Cag-A positive strains as a risk factor among different groups of ischemic heart disease and to study its interaction with high sensitivity CRP (hs-CRP) and IL6 as inflammatory host responses. The present study was conducted on anti H. pylori IgG positive 60 ischemic heart disease (IHD) patients and 20 apparently healthy individuals as a control group. IHD patients were classified into 3 groups: (group I) with acute myocardial infarction, unstable angina pectoris patients (group II), chronic stable angina pectoris patients (group III). For all patients and control groups serum anti Cag-A IgG, IL6, hs-CRP, CK, CKMB, LDH, AST and Lipid profile were estimated. IL6 and hs-CRP levels were increased in groups I, II and III as compared with group IV (P < 0.001) with positive correlation between IL6 and hs-CRP in groups I, II and III (P < 0.05). The percentage of anti Cag-A positive cases was similar among the patient groups, but significantly higher than in the control group. Thus, infection with Cag-A positive H. pylori strain may play a role as a risk factor in development of ischemic heart diseases through provocation of high inflammatory response or through other mechanism. Therefore eradication of this infection is important as it is much less expensive than long term treatment of the other risk factors.
Noha El-Mashad; Wafaa M El-Emshaty; Manal S Arfat; Bothina A Koura; Shereen S Metwally
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Egyptian journal of immunology / Egyptian Association of Immunologists     Volume:  16     ISSN:  1110-4902     ISO Abbreviation:  Egypt J Immunol     Publication Date:  2009  
Date Detail:
Created Date:  2010-08-23     Completed Date:  2010-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9816016     Medline TA:  Egypt J Immunol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  39-47     Citation Subset:  IM    
Clinical Pathology Department, Faculty of Medicine, Mansoura University, Egypt.
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MeSH Terms
Antibodies, Bacterial / blood,  immunology
Antigens, Bacterial / immunology*
Bacterial Proteins / immunology*
Helicobacter Infections / blood,  complications,  immunology*
Helicobacter pylori / immunology*
Immunoglobulin G / blood,  immunology
Inflammation / blood,  immunology
Inflammation Mediators / blood,  immunology*
Middle Aged
Myocardial Ischemia / blood,  etiology,  immunology*
Risk Factors
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Antigens, Bacterial; 0/Bacterial Proteins; 0/Immunoglobulin G; 0/Inflammation Mediators; 0/cagA protein, Helicobacter pylori

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