Document Detail

Relation of the CD36 gene A52C polymorphism to the risk of colorectal cancer among Japanese, with reference to with the aldehyde dehydrogenase 2 gene Glu487Lys polymorphism and drinking habit.
MedLine Citation:
PMID:  15780035     Owner:  NLM     Status:  MEDLINE    
High consumption of white meat (or saturated fatty acids) and alcohol has been demonstrated to have a tendency to increase the risk of colorectal cancer, according to the level of malondialdehyde-deoxyguanosine adducts derived from lipid per-oxidation in the colorectal mucosa. CD36 plays important roles as a long-chain fatty acid translocase and oxidized low-density lipoprotein (LDL) scavenger, while alcohol is metabolized by aldehyde dehydrogenase 2 (ALDH2) and decreases transiently metabolism of dietary fat and serum lipids. To examine associations between the risk of colorectal cancer and the CD36 gene A52C polymorphism according to the ALDH2 gene Glu487Lys polymorphism and drinking habit, a hospital-based case-control study was conducted with 128 colorectal cancer cases and 238 cancer-free controls. Odds ratios (ORs) for the C/C genotype relative to the A/A genotype were 1.70 [95% confidence interval (CI), 0.76-4.11] and 4.24 (95% CI, 1.42-22.66) for men and women, respectively, with the low-activity (Glu/Lys + Lys/Lys) ALDH2 genotype. The high-activity (Glu/Glu) genotype for men and women had no associations. On the other hand, the OR for the C/C genotype with high frequency of drinking habit relative to the A/A genotype with low frequency of drinking habit among men was 3.63 (95% CI, 1.29-13.15). The number of women with a high frequency drinking habit was too small for any corresponding analyses. Our findings suggest a significant interaction between alcohol consumption and the CD36 gene A52C polymorphism related to the metabolism of long-chain fatty acids and oxidized LDL in the etiology of colorectal cancer.
Kiyonori Kuriki; Nobuyuki Hamajima; Hitochi Chiba; Yukihide Kanemitsu; Takashi Hirai; Tomoyuki Kato; Toshiko Saito; Keitaro Matsuo; Koichi Koike; Shinkan Tokudome; Kazuo Tajima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Asian Pacific journal of cancer prevention : APJCP     Volume:  6     ISSN:  1513-7368     ISO Abbreviation:  Asian Pac. J. Cancer Prev.     Publication Date:    2005 Jan-Mar
Date Detail:
Created Date:  2005-03-22     Completed Date:  2005-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101130625     Medline TA:  Asian Pac J Cancer Prev     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  62-8     Citation Subset:  IM    
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681 Japan.
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MeSH Terms
Alcohol Drinking / adverse effects*,  epidemiology
Aldehyde Dehydrogenase / genetics*
Antigens, CD36 / genetics
Asian Continental Ancestry Group
Case-Control Studies
Chi-Square Distribution
Colorectal Neoplasms / enzymology,  genetics*
Genetic Predisposition to Disease / epidemiology
Japan / epidemiology
Middle Aged
Polymorphism, Genetic*
Risk Factors
Reg. No./Substance:
0/Antigens, CD36; EC protein, human; EC Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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