Document Detail

Relation of bosentan, iloprost, and sildenafil with growth factor levels in monocrotaline-induced pulmonary hypertension.
MedLine Citation:
PMID:  22468718     Owner:  NLM     Status:  MEDLINE    
It is believed that growth factors play an important role in vascular remodeling that is evident in pulmonary hypertension (PH) pathogenesis. In the present study, the vascular endothelial growth factor (VEGF) levels in serum and pulmonary artery samples of rats have been analyzed with monocrotaline (MCT)-induced PH after treatments with iloprost, bosentan, and sildenafil. Serum VEGF and pulmonary artery VEGF levels were found to be significantly lower in MCT groups compared with control groups and significantly higher in treatment groups compared with MCT groups. In conclusion, treatment strategies directed at increasing VEGF levels may be reasonable in PH management.
Semra Yigitaslan; Basar Sirmagul
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Publication Detail:
Type:  Journal Article     Date:  2012-04-02
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  34     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-13     Completed Date:  2012-08-23     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  222-9     Citation Subset:  IM    
Department of Pharmacology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Blood Pressure / drug effects
Hypertension, Pulmonary / blood*,  chemically induced,  drug therapy*,  physiopathology
Iloprost / therapeutic use*
Monocrotaline / toxicity
Piperazines / therapeutic use*
Pulmonary Artery / metabolism
Purines / therapeutic use
Rats, Sprague-Dawley
Sulfonamides / therapeutic use*
Sulfones / therapeutic use*
Transforming Growth Factor beta / blood,  metabolism
Vascular Endothelial Growth Factor A / blood,  metabolism
Vasodilator Agents / therapeutic use
Reg. No./Substance:
0/Antihypertensive Agents; 0/Piperazines; 0/Purines; 0/Sulfonamides; 0/Sulfones; 0/Transforming Growth Factor beta; 0/Vascular Endothelial Growth Factor A; 0/Vasodilator Agents; 0/vascular endothelial growth factor A, rat; 315-22-0/Monocrotaline; 3M7OB98Y7H/sildenafil; 78919-13-8/Iloprost; Q326023R30/bosentan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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