| Relation of Bosentan, Iloprost, and Sildenafil with Growth Factor Levels in Monocrotaline-Induced Pulmonary Hypertension. | |
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MedLine Citation:
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PMID: 22468718 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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It is believed that growth factors play an important role in vascular remodeling that is evident in pulmonary hypertension (PH) pathogenesis. In the present study, the vascular endothelial growth factor (VEGF) levels in serum and pulmonary artery samples of rats have been analyzed with monocrotaline (MCT)-induced PH after treatments with iloprost, bosentan, and sildenafil. Serum VEGF and pulmonary artery VEGF levels were found to be significantly lower in MCT groups compared with control groups and significantly higher in treatment groups compared with MCT groups. In conclusion, treatment strategies directed at increasing VEGF levels may be reasonable in PH management. |
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Authors:
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Semra Yigitaslan; Basar Sirmagul |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-2 |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: - ISSN: 1525-6006 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pharmacology, Faculty of Medicine, Eskisehir Osmangazi University , Eskisehir , Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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