Document Detail


A relation between near-wall particle-hemodynamics and onset of thrombus formation in abdominal aortic aneurysms.
MedLine Citation:
PMID:  21373952     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel computational particle-hemodynamics analysis of key criteria for the onset of an intraluminal thrombus (ILT) in a patient-specific abdominal aortic aneurysm (AAA) is presented. The focus is on enhanced platelet and white blood cell residence times as well as their elevated surface-shear loads in near-wall regions of the AAA sac. The generalized results support the hypothesis that a patient's AAA geometry and associated particle-hemodynamics have the potential to entrap activated blood particles, which will play a role in the onset of ILT. Although the ILT history of only a single patient was considered, the modeling and simulation methodology provided allow for the development of an efficient computational tool to predict the onset of ILT formation in complex patient-specific cases.
Authors:
C Basciano; C Kleinstreuer; S Hyun; E A Finol
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-03-04
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  39     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-09     Completed Date:  2012-02-24     Revised Date:  2014-10-23    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2010-26     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Abdominal / pathology,  physiopathology*
Aortic Aneurysm, Abdominal / complications,  physiopathology*
Blood Platelets*
Computer Simulation
Humans
Leukocytes*
Models, Cardiovascular*
Shear Strength
Thrombosis / etiology,  physiopathology*
Grant Support
ID/Acronym/Agency:
R15 HL087268/HL/NHLBI NIH HHS; R15HL087268/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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