| Relation between maternal angiogenic factors and utero-placental resistance in normal first- and second-trimester pregnancies. | |
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MedLine Citation:
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PMID: 20726742 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective. Soluble endoglin (sEng) is a novel antiangiogenic protein and elevated sEng concentrations in maternal circulation are closely related to preeclampsia and HELLP syndrome. As the perfusion of the uterine arteries as well as the dynamics of angiogenic factors between first and second trimester have prognostic value regarding pregnancy outcome, it was the aim of this study to investigate the relation between maternal angiogenic factors and uterine Doppler parameters. Study design. The longitudinal study includes 50 normal pregnancies. Pulsatility index (PI) of the uterine arteries was detected by Doppler ultrasound in first and second trimester. In parallel, maternal sEng and soluble fms-like tyrosine kinase 1 (sFlt1) concentration was measured using ELISA. Results. In the first trimester, the sEng concentrations were 4.92 ± 1.36 ng/mL and the uterine PI was 1.14 ± 0.28. In the second trimester, the maternal sEng concentration decreased significantly to 3.99 ± 0.63 ng/mL (p < 0.05) which was associated by a decrease of the uterine PI to 0.78 ± 0.15 (p < 0.001). Soluble fms-like tyrosine kinase 1 concentrations did not differ significantly between first and second trimester (423 ± 333 vs. 444 ± 291 pg/mL). There was a significant negative correlation between sEng and uterine resistance in the second trimester (r = -0.416; p < 0.001). Conclusions. In normal pregnancy, parallel to the fall of utero-placental resistance, there is a physiological decline of the maternal sEng concentration between first and second trimester. In second trimester, there is a negative correlation between sEng and uterine Doppler parameters. |
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Authors:
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Katrin Petzold; Alexander Jank; Renaldo Faber; Holger Stepan |
Publication Detail:
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Type: Journal Article Date: 2010-08-20 |
Journal Detail:
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Title: Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy Volume: 30 ISSN: 1525-6065 ISO Abbreviation: Hypertens Pregnancy Publication Date: 2011 |
Date Detail:
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Created Date: 2011-09-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421297 Medline TA: Hypertens Pregnancy Country: England |
Other Details:
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Languages: eng Pagination: 401-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, University Hospital of Leipzig , Leipzig , Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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