Document Detail

Relation between maternal angiogenic factors and utero-placental resistance in normal first- and second-trimester pregnancies.
MedLine Citation:
PMID:  20726742     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Soluble endoglin (sEng) is a novel antiangiogenic protein and elevated sEng concentrations in maternal circulation are closely related to preeclampsia and HELLP syndrome. As the perfusion of the uterine arteries as well as the dynamics of angiogenic factors between first and second trimester have prognostic value regarding pregnancy outcome, it was the aim of this study to investigate the relation between maternal angiogenic factors and uterine Doppler parameters.
STUDY DESIGN: The longitudinal study includes 50 normal pregnancies. Pulsatility index (PI) of the uterine arteries was detected by Doppler ultrasound in first and second trimester. In parallel, maternal sEng and soluble fms-like tyrosine kinase 1 (sFlt1) concentration was measured using ELISA.
RESULTS: In the first trimester, the sEng concentrations were 4.92 ± 1.36 ng/mL and the uterine PI was 1.14 ± 0.28. In the second trimester, the maternal sEng concentration decreased significantly to 3.99 ± 0.63 ng/mL (p < 0.05) which was associated by a decrease of the uterine PI to 0.78 ± 0.15 (p < 0.001). Soluble fms-like tyrosine kinase 1 concentrations did not differ significantly between first and second trimester (423 ± 333 vs. 444 ± 291 pg/mL). There was a significant negative correlation between sEng and uterine resistance in the second trimester (r = -0.416; p < 0.001).
CONCLUSIONS: In normal pregnancy, parallel to the fall of utero-placental resistance, there is a physiological decline of the maternal sEng concentration between first and second trimester. In second trimester, there is a negative correlation between sEng and uterine Doppler parameters.
Katrin Petzold; Alexander Jank; Renaldo Faber; Holger Stepan
Publication Detail:
Type:  Journal Article     Date:  2010-08-20
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  30     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2011  
Date Detail:
Created Date:  2011-09-30     Completed Date:  2012-01-19     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  401-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Angiogenesis Inducing Agents / blood*
Antigens, CD / blood*
Capillary Resistance
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Laser-Doppler Flowmetry
Longitudinal Studies
Placenta / blood supply*,  physiology,  ultrasonography
Pregnancy / physiology*
Pregnancy Trimester, First
Pregnancy Trimester, Second
Prospective Studies
Pulsatile Flow
Receptors, Cell Surface / blood*
Regional Blood Flow
Ultrasonography, Prenatal*
Uterus / blood supply*,  physiology,  ultrasonography
Young Adult
Reg. No./Substance:
0/Angiogenesis Inducing Agents; 0/Antigens, CD; 0/ENG protein, human; 0/Receptors, Cell Surface

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Biomechanical validation of upper extremity exercise in wheelchair users: design considerations and ...
Next Document:  Body mass index and blood pressure measurement during pregnancy.