Document Detail


Relation between digital peripheral arterial tonometry and brachial artery ultrasound measures of vascular function in patients with coronary artery disease and in healthy volunteers.
MedLine Citation:
PMID:  22154090     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Digital peripheral arterial tonometry (PAT) is an emerging, noninvasive method to assess vascular function. The physiology underlying this phenotype, however, remains unclear. Therefore, we evaluated the relation between digital PAT and established brachial artery ultrasound measures of vascular function under basal conditions and after reactive hyperemia. Using a cross-sectional study design, digital PAT and brachial artery ultrasonography with pulsed wave Doppler were simultaneously completed at baseline and after reactive hyperemia in both those with established coronary artery disease (n = 99) and healthy volunteers with low cardiovascular disease risk (n = 40). Under basal conditions, the digital pulse volume amplitude demonstrated a significant positive correlation with the brachial artery velocity-time integral that was independent of the arterial diameter, in both the healthy volunteer (r(s) = 0.64, p <0.001) and coronary artery disease (r(s) = 0.63, p <0.001) cohorts. Similar positive relations were observed with the baseline brachial artery blood flow velocity and blood flow. In contrast, no relation between the reactive hyperemia-evoked digital PAT ratio and either brachial artery flow-mediated dilation or shear stress was observed in either cohort (p = NS). In conclusion, these findings demonstrate that the digital PAT measures of vascular function more closely reflect basal blood flow in the brachial artery than reactive hyperemia-induced changes in the arterial diameter or flow velocity, and the presence of vascular disease does not modify the physiology underlying the digital PAT phenotype.
Authors:
Craig R Lee; Almasa Bass; Kyle Ellis; Bryant Tran; Savanna Steele; Melissa Caughey; George A Stouffer; Alan L Hinderliter
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-12-06
Journal Detail:
Title:  The American journal of cardiology     Volume:  109     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-27     Completed Date:  2012-04-24     Revised Date:  2013-07-22    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  651-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA. craig_lee@unc.edu
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MeSH Terms
Descriptor/Qualifier:
Automatic Data Processing*
Blood Flow Velocity / physiology*
Brachial Artery / physiopathology*,  ultrasonography
Coronary Artery Disease / diagnosis,  physiopathology*
Cross-Sectional Studies
Female
Follow-Up Studies
Humans
Male
Manometry / methods*
Middle Aged
Reproducibility of Results
Ultrasonography, Doppler, Pulsed / methods*
Ultrasonography, Interventional / methods*
Grant Support
ID/Acronym/Agency:
M01 RR000046/RR/NCRR NIH HHS; M01RR00046/RR/NCRR NIH HHS; UL1 RR025747/RR/NCRR NIH HHS; UL1 RR025747-03/RR/NCRR NIH HHS; UL1 RR025747-04/RR/NCRR NIH HHS; UL1RR025747/RR/NCRR NIH HHS
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