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The Relation Between Adult-Dark Spermatogonia and Other Parameters of Fertility Potential in Cryptorchid Testes.
MedLine Citation:
PMID:  23357211     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: The fertility potential of boys with cryptorchidism may be related to the number of adult-dark spermatogonia per tubular transverse section (Ad-S/T) in testicular biopsies taken at orchiopexy. Placental-like alkaline phosphatase (PLAP) positive gonocytes in testes within the first year of life indicate the preserved ability for germ cell transformation. The aim of the study was to relate these parameters to the total tubular germ cell number (S/T) and other factors associated to the fertility potential. METHODS: 89 boys 0.7-3 years (median:1.8) with bilateral testicular biopsy at bilateral orchiopexy and blood samples for gonadotropins and inhibin-B. RESULTS: In boys with Ad-Spermatogonia 58%(44/76) had normal mean S/T compared to 15%(2/13) among boys without Ad-Spermatogonia(p<0.05). In the group with a good fertility potential (n=30) including normal mean S/T, normal gonadotropins and normal inhibin-B the mean Ad-S/T was median 0.081 compared to median 0.031 in the group of patients with low fertility potential (n=38) including impaired S/T, and/or low inhibin-B but no reactive increase of gonadotropins (p<0.05). The group with increased gonadotropins (n=21) had mean Ad-S/T with median 0.063. 60%(12/20) of the patients with normal mean Ad-S/T belonged to the group with good fertility potential including normal mean S/T, normal gonadotropins and inhibin-B compared to only 26%(18/69) of boys with impaired mean Ad-S/T (p<0.05). In boys with a normal mean S/T 57% (26/46) had PLAP positive cells compared to 33%(14/43) in boys with decreased mean S/T, (p<0.05). CONCLUSION: Notification of PLAP positive gonocytes and Ad-S/T are important parameters related to the fertility potential of cryptorchid testes.
Authors:
Jorgen Thorup; Kolja Kvist; Erik Clasen-Linde; Bodil Laub Petersen; Dina Cortes
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-25
Journal Detail:
Title:  The Journal of urology     Volume:  -     ISSN:  1527-3792     ISO Abbreviation:  J. Urol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
Affiliation:
The Department of Pediatric Surgery, Rigshospitalet, DK-2100 Copenhagen; Faculty of Health Science, University of Copenhagen.
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