Document Detail

Relation of B-type natriuretic peptide level in heart failure to sudden cardiac death in patients with and without QT interval prolongation.
MedLine Citation:
PMID:  23273526     Owner:  NLM     Status:  MEDLINE    
Increased levels of B-type natriuretic peptide (BNP) are associated with prolongation of the action potential in ventricular myocardium. We investigated the relation of a BNP increase, QT interval, and sudden cardiac death (SCD) in the presence of heart failure (HF). We enrolled 398 patients with HF, New York Heart Association class III or IV, and left ventricular ejection fraction <40%. At baseline and after 3 months, we measured BNP and the QT interval. A BNP increase was defined as a change in BNP of ≥+10%. The QTc interval was calculated using the Bazett formula. QTc interval prolongation was defined as a change in QTc of ≥+10%. The patients were followed up for 1 year. During a 3-month period, BNP increased significantly in 53% of the patients (group 1) and did not in 47% (group 2). During the same period, the QTc interval was more prolonged in group 1 (+44 ± 12 ms) than in group 2 (+7 ± 6 ms; p = 0.01). During 1 year of follow-up, 20 patients died suddenly (SCD), 16 from pump failure. Although the SCD rates did not differ between the 2 groups (5.7% in group 1 vs 4.2% in group 2, p = 0.53), they were significantly greater in the patients in group 1 with QTc interval prolongation ≥+10% (13.8%, p <0.001). The Kaplan-Meier-derived SCD-free survival rates were 2.9 times greater in patients without QTc interval prolongation than in those with prolonged QTc (p <0.001). QTc interval prolongation was an independent correlate of SCD (p = 0.006), but BNP increase was not (p = 0.32). In conclusion, a BNP increase in patients with HF was associated with an increased risk of SCD only in patients with QTc interval prolongation.
Bojan Vrtovec; Ivan Knezevic; Gregor Poglajen; Miran Sebestjen; Renata Okrajsek; François Haddad
Related Documents :
20735296 - Restoration of retinal architecture following systemic immunosuppression in birdshot ch...
23542726 - Puerperal development of ewes following dystocia: a retrospective analysis of two appro...
25492556 - Endoluminal thoracic aortic repair in the octogenarian and nonagenarian: the new zealan...
25073206 - Mid-term follow-up after maze iv procedures for concomitant atrial fibrillation.
20630056 - Bendiocarb, a potential alternative against pyrethroid resistant anopheles gambiae in b...
19195416 - Lower incidence of procoagulant abnormalities during follow-up after creation of the fo...
Publication Detail:
Type:  Journal Article     Date:  2012-12-28
Journal Detail:
Title:  The American journal of cardiology     Volume:  111     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-05-16     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  886-90     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Advanced Heart Failure and Transplantation Center, Department of Cardiology, University Medical Center Ljubljana, Ljubljana, Slovenia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / blood
Chi-Square Distribution
Death, Sudden, Cardiac / epidemiology,  etiology*
Heart Failure / blood*,  complications*,  epidemiology
Long QT Syndrome / blood*,  complications*,  epidemiology
Middle Aged
Natriuretic Peptide, Brain / blood*
Proportional Hazards Models
Prospective Studies
Risk Factors
Survival Rate
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain
Comment In:
Future Cardiol. 2013 May;9(3):317-20   [PMID:  23668737 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Incidence and Relevance of Acute Kidney Injury in Patients Hospitalized With Acute Coronary Syndrome...
Next Document:  Evaluation of framingham and systematic coronary risk evaluation scores by coronary computed tomogra...