Document Detail


Relating pulmonary oxygen uptake to muscle oxygen consumption at exercise onset: in vivo and in silico studies.
MedLine Citation:
PMID:  16636861     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Assessment of the rate of muscle oxygen consumption, UO(2m), in vivo during exercise involving a large muscle mass is critical for investigating mechanisms regulating energy metabolism at exercise onset. While UO(2m) is technically difficult to obtain under these circumstances, pulmonary oxygen uptake, VO(2p), can be readily measured and used as a proxy to UO(2m). However, the quantitative relationship between VO(2p) and UO(2m) during the nonsteady phase of exercise in humans, needs to be established. A computational model of oxygen transport and utilization--based on dynamic mass balances in blood and tissue cells--was applied to quantify the dynamic relationship between model-simulated UO(2m) and measured VO(2p) during moderate (M), heavy (H), and very heavy (V) intensity exercise. In seven human subjects, VO(2p) and muscle oxygen saturation, StO(2m), were measured with indirect calorimetry and near infrared spectroscopy (NIRS), respectively. The dynamic responses of VO(2p) and StO(2m) at each intensity were in agreement with previously published data. The response time of muscle oxygen consumption, tauUO(2m) estimated by direct comparison between model results and measurements of StO(2m) was significantly faster (P < 0.001) than that of pulmonary oxygen uptake, tauVO(2p) (M: 13 +/- 4 vs. 65 +/- 7 s; H: 13 +/- 4 vs. 100 +/- 24 s; V: 15 +/- 5 vs. 82 +/- 31 s). Thus, by taking into account the dynamics of oxygen stores in blood and tissue and determining muscle oxygen consumption from muscle oxygenation measurements, this study demonstrates a significant temporal dissociation between UO(2m) and VO(2p) at exercise onset.
Authors:
N Lai; R K Dash; M M Nasca; G M Saidel; M E Cabrera
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2006-04-25
Journal Detail:
Title:  European journal of applied physiology     Volume:  97     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-28     Completed Date:  2006-09-22     Revised Date:  2014-08-08    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  380-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Computer Simulation
Energy Metabolism
Exercise / physiology*
Exercise Test
Humans
Male
Models, Biological*
Muscle, Skeletal / blood supply,  metabolism*
Oxygen / metabolism*
Oxygen Consumption
Pulmonary Gas Exchange*
Regional Blood Flow
Time Factors
Grant Support
ID/Acronym/Agency:
GM-66309-01/GM/NIGMS NIH HHS; P50 GM066309/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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