| Relating olfactory neurotoxicity to altered olfactory-mediated behaviors in rainbow trout exposed to three currently-used pesticides. | |
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MedLine Citation:
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PMID: 17145086 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Odor-evoked neurophysiological responses can form the basis for behavioral responses. Here we first characterized olfactory-mediated behavioral and neurophysiological responses of juvenile rainbow trout to the amino acid l-histidine, then looked at whether there were similar responses to the carbamate antisapstain IPBC and the herbicides atrazine and Roundup, and lastly explored how exposures to these pesticides modified the l-histidine responses. Trout were behaviorally attracted to 10(-7)M l-histidine (as assayed in a counter-current olfactometer), but this preference behavior switched to indifference with higher histidine concentrations. Neurophysiologically, the summed electrical responses of peripheral olfactory neurons, as measured using electro-olfactogram (EOG), was 0.843+/-0.252 mV to 10(-7)M l-histidine. Of the pesticides, only Roundup evoked EOGs, indicating the amino acid-based pesticide may have acted as an odorant, and generated a behavioral response: it was avoided at active ingredient [AI; glyphosate isopropyl amine] concentrations > or =10 mg/l. With 30 min pesticide exposures, 10(-7)M l-histidine preference behavior was eliminated following exposure to 1 microg/l IPBC and atrazine, and 100 microg/l AI Roundup. Similarly, 10(-7)M l-histidine-evoked EOGs were significantly reduced by exposure to 1 microg/l IPBC, 10 microg/l atrazine, and 100 microg/l AI Roundup. When combined together, the results demonstrate that typical preference behavior can be abolished when neurophysiological responses are reduced by >60% of control. This asymmetry in response thresholds suggests that behavioral responses may be more sensitive toxicological endpoints than neurophysiological responses. |
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Authors:
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Keith B Tierney; Christopher R Singh; Peter S Ross; Christopher J Kennedy |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-11-21 |
Journal Detail:
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Title: Aquatic toxicology (Amsterdam, Netherlands) Volume: 81 ISSN: 0166-445X ISO Abbreviation: Aquat. Toxicol. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-17 Completed Date: 2007-04-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500246 Medline TA: Aquat Toxicol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 55-64 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrazine / toxicity* Behavior, Animal / drug effects Carbamates / toxicity* Electrophysiology Glycine / analogs & derivatives*, toxicity Histidine / pharmacology Olfactory Receptor Neurons / drug effects*, physiology Oncorhynchus mykiss / physiology* Pesticides / toxicity* Smell / drug effects Time Factors Water Pollutants, Chemical / toxicity |
| Chemical | |
Reg. No./Substance:
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0/Carbamates; 0/Pesticides; 0/Water Pollutants, Chemical; 1071-83-6/glyphosate; 1912-24-9/Atrazine; 55406-53-6/3-iodo-2-propynylbutylcarbamate; 56-40-6/Glycine; 71-00-1/Histidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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