Document Detail


Relating olfactory neurotoxicity to altered olfactory-mediated behaviors in rainbow trout exposed to three currently-used pesticides.
MedLine Citation:
PMID:  17145086     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Odor-evoked neurophysiological responses can form the basis for behavioral responses. Here we first characterized olfactory-mediated behavioral and neurophysiological responses of juvenile rainbow trout to the amino acid l-histidine, then looked at whether there were similar responses to the carbamate antisapstain IPBC and the herbicides atrazine and Roundup, and lastly explored how exposures to these pesticides modified the l-histidine responses. Trout were behaviorally attracted to 10(-7)M l-histidine (as assayed in a counter-current olfactometer), but this preference behavior switched to indifference with higher histidine concentrations. Neurophysiologically, the summed electrical responses of peripheral olfactory neurons, as measured using electro-olfactogram (EOG), was 0.843+/-0.252 mV to 10(-7)M l-histidine. Of the pesticides, only Roundup evoked EOGs, indicating the amino acid-based pesticide may have acted as an odorant, and generated a behavioral response: it was avoided at active ingredient [AI; glyphosate isopropyl amine] concentrations > or =10 mg/l. With 30 min pesticide exposures, 10(-7)M l-histidine preference behavior was eliminated following exposure to 1 microg/l IPBC and atrazine, and 100 microg/l AI Roundup. Similarly, 10(-7)M l-histidine-evoked EOGs were significantly reduced by exposure to 1 microg/l IPBC, 10 microg/l atrazine, and 100 microg/l AI Roundup. When combined together, the results demonstrate that typical preference behavior can be abolished when neurophysiological responses are reduced by >60% of control. This asymmetry in response thresholds suggests that behavioral responses may be more sensitive toxicological endpoints than neurophysiological responses.
Authors:
Keith B Tierney; Christopher R Singh; Peter S Ross; Christopher J Kennedy
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-21
Journal Detail:
Title:  Aquatic toxicology (Amsterdam, Netherlands)     Volume:  81     ISSN:  0166-445X     ISO Abbreviation:  Aquat. Toxicol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-17     Completed Date:  2007-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500246     Medline TA:  Aquat Toxicol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  55-64     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrazine / toxicity*
Behavior, Animal / drug effects
Carbamates / toxicity*
Electrophysiology
Glycine / analogs & derivatives*,  toxicity
Histidine / pharmacology
Olfactory Receptor Neurons / drug effects*,  physiology
Oncorhynchus mykiss / physiology*
Pesticides / toxicity*
Smell / drug effects
Time Factors
Water Pollutants, Chemical / toxicity
Chemical
Reg. No./Substance:
0/Carbamates; 0/Pesticides; 0/Water Pollutants, Chemical; 1071-83-6/glyphosate; 1912-24-9/Atrazine; 55406-53-6/3-iodo-2-propynylbutylcarbamate; 56-40-6/Glycine; 71-00-1/Histidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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