Document Detail


Relating components of pressure-volume area in Suga's formulation of cardiac energetics to components of the stress-time integral.
MedLine Citation:
PMID:  22837173     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concept of pressure-volume area (PVA) in whole heart studies is central to the phenomenological description of cardiac energetics proposed by Suga and colleagues (Physiol Rev 70: 247-277, 1990). PVA consists of two components: an approximately rectangular work loop (W) and an approximately triangular region of potential energy (U). In the case of isovolumic contractions, PVA consists entirely of U. The utility of Suga's description of cardiac energetics is the observation that the oxygen consumption of the heart (Vo(2)) is linearly dependent on PVA. By using isolated ventricular trabeculae, we found a basis on which to correlate the components of stress-length area (SLA; i.e., the 1-D equivalent of PVA) with specific regions of the stress-time integral (STI; i.e., the area under the force-time profile of a single twitch). In each case, proportionality obtains and is robust, independent of the type of twitch contraction (isometric or isotonic), and insensitive to changes of preload or afterload. We apply our results by examining retrospectively the interpretations reached in three independent studies published in the literature.
Authors:
J-C Han; A J Taberner; K Tran; D P Nickerson; M P Nash; P M F Nielsen; E J Crampin; D S Loiselle
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-07-26
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  113     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-05-23     Revised Date:  2013-10-10    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  988-95     Citation Subset:  IM    
Affiliation:
Auckland Bioengineering Institute, Auckland, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Energy Metabolism
Heart Ventricles / metabolism
Myocardial Contraction / physiology*
Myocardium / metabolism*
Oxygen Consumption / physiology*
Pressure
Grant Support
ID/Acronym/Agency:
P50-GM094503/GM/NIGMS NIH HHS
Comments/Corrections

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