Document Detail


Relating brain damage to brain plasticity in patients with multiple sclerosis.
MedLine Citation:
PMID:  22328685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Failure of adaptive plasticity with increasing pathology is suggested to contribute to progression of disability in multiple sclerosis (MS). However, functional impairments can be reduced with practice, suggesting that brain plasticity is preserved even in patients with substantial damage.
OBJECTIVE: . Here, functional magnetic resonance imaging (fMRI) was used to probe systems-level mechanisms of brain plasticity associated with improvements in visuomotor performance in MS patients and related to measures of microstructural damage.
METHODS: 23 MS patients and 12 healthy controls underwent brain fMRI during the first practice session of a visuomotor task (short-term practice) and after 2 weeks of daily practice with the same task (longer-term practice). Participants also underwent a structural brain MRI scan.
RESULTS: Patients performed more poorly than controls at baseline. Nonetheless, with practice, patients showed performance improvements similar to controls and independent of the extent of MRI measures of brain pathology. Different relationships between performance improvements and activations were found between groups: greater short-term improvements were associated with lower activation in the sensorimotor, posterior cingulate, and parahippocampal cortices for patients, whereas greater long-term improvements correlated with smaller activation reductions in the visual cortex of controls.
CONCLUSIONS: Brain plasticity for visuomotor practice is preserved in MS patients despite a high burden of cerebral pathology. Cognitive systems different from those acting in controls contribute to this plasticity in patients. These findings challenge the notion that increasing pathology is accompanied by an outright failure of adaptive plasticity, supporting a neuroscientific rationale for recovery-oriented strategies even in chronically disabled patients.
Authors:
Valentina Tomassini; Heidi Johansen-Berg; Saad Jbabdi; Richard G Wise; Carlo Pozzilli; Jacqueline Palace; Paul M Matthews
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-09
Journal Detail:
Title:  Neurorehabilitation and neural repair     Volume:  26     ISSN:  1552-6844     ISO Abbreviation:  Neurorehabil Neural Repair     Publication Date:    2012 Jul-Aug
Date Detail:
Created Date:  2012-07-09     Completed Date:  2012-11-29     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  100892086     Medline TA:  Neurorehabil Neural Repair     Country:  United States    
Other Details:
Languages:  eng     Pagination:  581-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anisotropy
Brain / blood supply,  pathology*,  physiopathology*
Brain Mapping
Disability Evaluation
Female
Functional Laterality / physiology
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Motor Skills
Multiple Sclerosis* / pathology,  physiopathology,  rehabilitation
Neuronal Plasticity / physiology*
Neuropsychological Tests
Oxygen / blood
Photic Stimulation
Practice (Psychology)*
Psychomotor Performance / physiology*
Statistics as Topic
Grant Support
ID/Acronym/Agency:
090955//Wellcome Trust; G0700399//Medical Research Council; G9409531//Medical Research Council; //Medical Research Council; //Wellcome Trust
Chemical
Reg. No./Substance:
S88TT14065/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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