| Relapsing-remitting multiple sclerosis and human herpesvirus 6 active infection. | |
| | |
MedLine Citation:
|
PMID: 15477505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Recent studies have focused on the relationship between human herpesvirus 6 (HHV-6) and multiple sclerosis (MS). OBJECTIVE: To analyze HHV-6 messenger RNA expression in patients with relapsing-remitting (RR) MS vs healthy blood donors (HBDs). DESIGN: One hundred fifty-four subjects were enrolled in the study: 105 patients with RRMS (32 in relapse) and 49 HBDs. Total DNA and messenger RNA were extracted from serum and blood samples, respectively, and analyzed by quantitative real-time reverse transcription-polymerase chain reaction for the detection of 3 HHV-6 immediate-early genes (U16/U17,U89/U90, and U94) and both HHV-6 variants (HHV-6A and HHV-6B). RESULTS: Active HHV-6 infection was detected in 16% of patients with RRMS vs 0% of HBDs (P = .003). Seven patients with RRMS with exacerbation had HHV-6 active replication, and the virus remained latent in only 1 of them. We did not find any statistically significant difference between HHV-6 active or latent infection for patients in remission (P = .12). Among patients with RRMS with HHV-6 active replication, viral load was higher when they experienced an acute attack than when in remission (P = .04). In those patients with RRMS who had an active infection only, HHV-6A was found. Cell-free HHV-6 DNA detected in serum samples confirmed the results. CONCLUSIONS: The results show that a subset of patients with RRMS experience HHV-6 active infection, and there likely is an association between the viral active replication and relapses; therefore, HHV-6 active infection may imply a greater risk of exacerbations in a subgroup of patients with RRMS. |
| | |
Authors:
|
Roberto Alvarez-Lafuente; Virginia De las Heras; Manuel Bartolomé; Juan José Picazo; Rafael Arroyo |
Related Documents
:
|
17362465 - Immune recovery uveitis in an hiv-negative individual. 8560985 - Cytomegalovirus infection of the brain in aids: a clinicopathological study. 7993245 - Biliary dilatation in asymptomatic aids patients. 12099745 - Viral studies in the cerebrospinal fluid in subacute sclerosing panencephalitis. 20530405 - Stigma and otherness in the israeli media's mirror representations of illness. 12766695 - Neurocognitive manifestations of human immunodeficiency virus. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Archives of neurology Volume: 61 ISSN: 0003-9942 ISO Abbreviation: Arch. Neurol. Publication Date: 2004 Oct |
Date Detail:
|
Created Date: 2004-10-12 Completed Date: 2004-12-03 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
|
Languages: eng Pagination: 1523-7 Citation Subset: AIM; IM |
Affiliation:
|
Servicio de Neurología, Hospital Clínico San Carlos, 28040 Madrid, Spain. labesmul@hcsc.es |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult DNA, Viral / blood Female Herpesviridae Infections / blood, complications, virology* Herpesvirus 6, Human / genetics, isolation & purification* Humans Male Middle Aged Multiple Sclerosis, Relapsing-Remitting / blood, complications, virology* RNA, Messenger / biosynthesis Reverse Transcriptase Polymerase Chain Reaction / methods Viral Load / statistics & numerical data |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Viral; 0/RNA, Messenger |
| Comments/Corrections | |
Comment In:
|
Arch Neurol. 2004 Oct;61(10):1500-2
[PMID:
15477500
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intravenous immunoglobulin treatment following the first demyelinating event suggestive of multiple ...
Next Document: Cerebral white matter lesions and the risk of dementia.