Document Detail

Relapsing polychondritis in a patient with ankylosing spondylitis using etanercept.
MedLine Citation:
PMID:  25276463     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Relapsing polychondritis (RP) is an autoimmune disease characterized by recurrent episodes of inflammation and progressive destruction of cartilaginous tissues, especially of the ears, nose, joints, and tracheobronchial tree. Its etiology is not well understood, but some studies have linked its pathophysiology with autoimmune disease and autoantibody production. We described a case of a 46-year-old male patient with ankylosing spondylitis who developed RP after the use of etanercept. Few similar cases have been described in the literature. However, they show a possible association between the use of biological inhibitors of tumor necrosis factor (anti-TNFα), which potentially produces autoantibodies, and the development of RP. The treatment was based on data in the literature and included the cessation of biological therapy and the addition of corticosteroids with substantial improvement.
Valderilio Feijó Azevedo; Natalia Bassalobre Galli; Alais Daiane Fadini Kleinfelder; Julia Farabolini D'Ippolito; Andressa Gulin Tolentino; Eduardo Paiva
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Publication Detail:
Type:  Journal Article     Date:  2014-09-09
Journal Detail:
Title:  Case reports in rheumatology     Volume:  2014     ISSN:  2090-6889     ISO Abbreviation:  Case Rep Rheumatol     Publication Date:  2014  
Date Detail:
Created Date:  2014-10-03     Completed Date:  2014-10-03     Revised Date:  2014-10-04    
Medline Journal Info:
Nlm Unique ID:  101585353     Medline TA:  Case Rep Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  353782     Citation Subset:  -    
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