Document Detail

Relapse to smoking after 1 year of abstinence: a meta-analysis.
MedLine Citation:
PMID:  18706769     Owner:  NLM     Status:  MEDLINE    
Most clinical trials use 6 months or 1 year follow-ups as proxies for life-time smoking cessation. Retrospective studies have estimated 2-15% of smokers relapse each year after the first year of abstinence, but these have methodological problems such as memory bias. We searched for prospective studies of adult quitters that reported the number of participants abstinent at 1 yr follow-up and who remained abstinent at >or=2 year follow-ups. We included studies that reported the percent which remained lapse-free, did not continue treatment after 1 year, and had <or=10% lost-to-follow-up. We did not locate any population-based studies but did locate eight randomized, controlled trials, all testing nicotine medications. After deleting one trial with outlier results, a meta-analysis estimated the annual incidence of relapse after 1 year to be 10%; however, the small sample sizes resulted in a wide 95% confidence interval (5-17%) suggesting this estimate is not very accurate. We conclude a non-significant amount of relapse occurs after 1 year. Better quantification of this relapse rate is important to improve estimates of life-long abstinence and reductions in morbidity and mortality from smoking cessation.
John R Hughes; Erica N Peters; Shelly Naud
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural     Date:  2008-06-08
Journal Detail:
Title:  Addictive behaviors     Volume:  33     ISSN:  1873-6327     ISO Abbreviation:  Addict Behav     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2009-07-28     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  7603486     Medline TA:  Addict Behav     Country:  England    
Other Details:
Languages:  eng     Pagination:  1516-20     Citation Subset:  IM    
Department of Psychiatry, University of Vermont, Burlington, VT 05401, USA.
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MeSH Terms
Confidence Intervals
Prospective Studies
Smoking / epidemiology*
Smoking Cessation / statistics & numerical data*
Time Factors
Grant Support

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