Document Detail

Relapse to opiate use provokes biphasic changes of blood pressure in heroin-withdrawn addicts treated with clonidine.
MedLine Citation:
PMID:  1321712     Owner:  NLM     Status:  MEDLINE    
The effect of relapse to opiate use on blood pressure and heart rate has been studied in heroin-withdrawn addicts treated with clonidine in an outpatient detoxification procedure. The daily dose of clonidine was established according to body weight and amount of heroin usually consumed at the onset of treatment. Patients who returned to heroin use were detected by increased urinary levels of opiates. Clonidine elicited significant reductions of blood pressure and heart rate reaching a plateau in the second day of treatment. Heroin consumption was found to provoke a further decrease of both systolic and diastolic pressure when the time interval between the relapse and the cardiovascular determinations was about 3 h as estimated by the patients. At longer intervals (16 h) this effect was reversed and both the hypotensive and the bradycardiac actions of clonidine seemed to be impaired. The possible impact of endogenous opioids and alpha-2 receptor sensitivity on these biphasic alterations is discussed.
G Rubio; L F Alguacil; C Alamo; J Pascual; J R Lopez-Trabada
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  30     ISSN:  0376-8716     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-08-27     Completed Date:  1992-08-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM    
Plan Regional de Drogas, Madrid, Spain.
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MeSH Terms
Blood Pressure / drug effects*,  physiology
Clonidine / therapeutic use*
Dose-Response Relationship, Drug
Heroin / adverse effects*
Heroin Dependence / physiopathology,  rehabilitation*
Substance Abuse Treatment Centers
Substance Withdrawal Syndrome / physiopathology*
Reg. No./Substance:
4205-90-7/Clonidine; 561-27-3/Heroin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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