Document Detail


Relapse of enterococcal prosthetic valve endocarditis with aortic root abscess following treatment with daptomycin in a patient not fit for surgery.
MedLine Citation:
PMID:  20019148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Daptomycin is a novel lipopeptide with activity against Gram-positive organisms including enterococci. It is licensed for the treatment of Staphylococcus aureus bacteraemia and right-sided endocarditis, but not endocarditis due to Enterococcus spp. We report a case of enterococcal prosthetic valve endocarditis with an aortic root abscess in an elderly patient who was not fit for surgery. The patient's endocarditis relapsed 9 weeks after a 6 week course of daptomycin.
Authors:
D A Enoch; N Phillimore; J A Karas; L Horswill; D A Mlangeni
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-12-17
Journal Detail:
Title:  Journal of medical microbiology     Volume:  59     ISSN:  1473-5644     ISO Abbreviation:  J. Med. Microbiol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-17     Completed Date:  2010-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0224131     Medline TA:  J Med Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  482-5     Citation Subset:  IM    
Affiliation:
Clinical Microbiology and Public Health Laboratory, Peterborough District Hospital, Thorpe Road, Peterborough PE3 6JW, UK. david.enoch@pbh-tr.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Abscess / drug therapy,  etiology*
Aged
Aged, 80 and over
Amoxicillin / therapeutic use
Anti-Bacterial Agents / therapeutic use*
Aortic Valve / microbiology,  surgery*
Bacteremia / drug therapy,  etiology*
Daptomycin / therapeutic use*
Endocarditis, Bacterial / drug therapy,  etiology*
Enterococcus faecalis / drug effects,  isolation & purification*
Female
Heart Valve Prosthesis / adverse effects*
Humans
Recurrence
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 103060-53-3/Daptomycin; 26787-78-0/Amoxicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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