Document Detail


Relapse of depression during pregnancy following antidepressant discontinuation: a preliminary prospective study.
MedLine Citation:
PMID:  15338315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Pregnancy has frequently been referred to as a time of emotional well-being for patients. However, systematic data about the risk for relapse of depression during pregnancy are sparse. METHOD: We completed a longitudinal cohort study of thirty-two (N = 32) women with histories of depression who were euthymic at conception and who either discontinued or attempted to discontinue antidepressant therapy proximate to conception. Subjects were prospectively followed across pregnancy once per trimester using structured clinical interviews. Rates of relapse and time to relapse were examined. Factors distinguishing the population with respect to risk for relapse including demographic characteristics and illness history were also examined. RESULTS: Seventy-five percent (N = 24) of patients relapsed during pregnancy. The majority of relapses (79%, N = 19) occurred in the first trimester, and relapse was more prevalent in women with histories of more chronic depression. CONCLUSIONS: Pregnancy is not "protective" with respect to risk for relapse of depression. Careful treatment planning is necessary for those women on antidepressants who plan to conceive or who become pregnant.
Authors:
L S Cohen; R M Nonacs; J W Bailey; A C Viguera; A M Reminick; L L Altshuler; Z N Stowe; S V Faraone
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2004-08-30
Journal Detail:
Title:  Archives of women's mental health     Volume:  7     ISSN:  1434-1816     ISO Abbreviation:  Arch Womens Ment Health     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-13     Completed Date:  2004-12-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9815663     Medline TA:  Arch Womens Ment Health     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  217-21     Citation Subset:  IM    
Affiliation:
Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. lcohen2@partners.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Antidepressive Agents / administration & dosage*
Depressive Disorder / drug therapy,  psychology*
Female
Humans
Longitudinal Studies
Pregnancy
Pregnancy Complications / psychology*
Prospective Studies
Questionnaires
Recurrence
Risk Factors
Severity of Illness Index
Substance Withdrawal Syndrome / psychology*
Time Factors
Treatment Refusal / psychology*
Grant Support
ID/Acronym/Agency:
MH 19445/MH/NIMH NIH HHS; R01 MH 56420-05/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Antidepressive Agents

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