Document Detail

Relapse of Wegener's granulomatosis in the first trimester of pregnancy: a case report.
MedLine Citation:
PMID:  9566676     Owner:  NLM     Status:  MEDLINE    
The association of Wegener's granulomatosis and pregnancy is rare and poses unique therapeutic challenges, particularly when active disease presents in early pregnancy. We describe a 22-yr-old woman who recovered successfully from her initial episode of Wegener's granulomatosis with a standard course of treatment with prednisolone and cyclophosphamide. Two and a half years later, she presented with relapse during the first trimester of pregnancy (primigravida). Since the clinical features suggested mild disease, she was started on prednisolone at a dose of 1 mg/kg/day, to which she seemed to respond very well for 3 months. Unfortunately, she had a spontaneous abortion at 5 months of gestation while on 25 mg/day of prednisolone. At this time, her disease flared further, with clinically manifest lung disease which was not part of her initial presentation. She was treated with another course of oral cyclophosphamide and prednisolone, and a remission was achieved in 4 months. There are no agreed guidelines on the treatment of Wegener's granulomatosis during pregnancy. In this report, the therapeutic issues are discussed against the background of the available literature.
A Kumar; A Mohan; R Gupta; V K Singal; O P Garg
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British journal of rheumatology     Volume:  37     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-05-07     Completed Date:  1998-05-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  331-3     Citation Subset:  AIM; IM    
Clinical Immunology Service, Department of Medicine, All India Institute of Medical Sciences, New Delhi.
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MeSH Terms
Abortion, Spontaneous
Anti-Inflammatory Agents / administration & dosage
Prednisolone / administration & dosage
Pregnancy Complications / diagnosis*
Pregnancy Trimester, First
Wegener Granulomatosis / diagnosis*,  drug therapy
Reg. No./Substance:
0/Anti-Inflammatory Agents; 50-24-8/Prednisolone

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