Document Detail


RelB reduces thymocyte apoptosis and regulates terminal thymocyte maturation.
MedLine Citation:
PMID:  11753998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thymocyte maturation is controlled by successive developmental checkpoints connected to the acquisition of a functional T cell receptor (TCR). During thymocyte selection, engagement of the TCR regulates the fine balance between death and survival signals. At the final stages of single-positive (SP) thymocyte maturation, the coupling of the TCR changes from death- to proliferation-inducing signals, a competence required for optimal effector functions in the periphery. We show here that in RelB mutant thymuses, thymocyte differentiation of CD24(-) SP cells is partially impaired. Competitive bone marrow reconstitution experiments show that this defect is constitutive to the lymphoid compartment. This is accompanied by an increased proportion of apoptotic thymocytes and a drastically reduced proliferation upon activation with anti-CD3 antibody/PMA stimulation. Thus, the RelB protein contributes to the quality of cell signaling in thymocytes by providing anti-apoptotic signals. These results suggest that in addition to its major role on the activation of antigen-presenting cell function, the RelB protein is intrinsically required for terminal thymocyte differentiation and activation.
Authors:
Sandrine Guerin; Marie-Laurence Baron; René Valero; Magali Herrant; Patrick Auberger; Philippe Naquet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of immunology     Volume:  32     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-25     Completed Date:  2002-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Affiliation:
Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Université de la Méditerranée, Marseille, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis*
Cell Differentiation
Cell Division
Gene Expression
MAP Kinase Signaling System
Mice
Mice, Inbred C57BL
Mice, Knockout
NF-kappa B / antagonists & inhibitors*
Phenotype
Proto-Oncogene Proteins / genetics,  metabolism,  physiology*
Receptors, Antigen, T-Cell / immunology
Thymus Gland / cytology*
Transcription Factor RelB
Transcription Factors / genetics,  metabolism,  physiology*
Chemical
Reg. No./Substance:
0/NF-kappa B; 0/Proto-Oncogene Proteins; 0/Receptors, Antigen, T-Cell; 0/Relb protein, mouse; 0/Transcription Factors; 147337-75-5/Transcription Factor RelB

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