Document Detail


Rejuvenation of regeneration in the aging central nervous system.
MedLine Citation:
PMID:  22226359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Remyelination is a regenerative process in the central nervous system (CNS) that produces new myelin sheaths from adult stem cells. The decline in remyelination that occurs with advancing age poses a significant barrier to therapy in the CNS, particularly for long-term demyelinating diseases such as multiple sclerosis (MS). Here we show that remyelination of experimentally induced demyelination is enhanced in old mice exposed to a youthful systemic milieu through heterochronic parabiosis. Restored remyelination in old animals involves recruitment to the repairing lesions of blood-derived monocytes from the young parabiotic partner, and preventing this recruitment partially inhibits rejuvenation of remyelination. These data suggest that enhanced remyelinating activity requires both youthful monocytes and other factors, and that remyelination-enhancing therapies targeting endogenous cells can be effective throughout life.
Authors:
Julia M Ruckh; Jing-Wei Zhao; Jennifer L Shadrach; Peter van Wijngaarden; Tata Nageswara Rao; Amy J Wagers; Robin J M Franklin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell stem cell     Volume:  10     ISSN:  1875-9777     ISO Abbreviation:  Cell Stem Cell     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-09     Completed Date:  2012-05-01     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  101311472     Medline TA:  Cell Stem Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  96-103     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult Stem Cells / cytology,  metabolism*
Aging / metabolism*
Animals
Central Nervous System / cytology,  metabolism*
Mice
Mice, Knockout
Monocytes / cytology,  metabolism
Multiple Sclerosis / metabolism
Myelin Sheath / metabolism*
Regeneration / physiology*
Grant Support
ID/Acronym/Agency:
079249//Wellcome Trust; 1 DP2 OD004345-01/OD/NIH HHS; DP2 OD004345/OD/NIH HHS; G0800784//Medical Research Council; P30 DK036836/DK/NIDDK NIH HHS; P30 DK036836/DK/NIDDK NIH HHS; //Medical Research Council
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