| Rejuvenation of regeneration in the aging central nervous system. | |
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MedLine Citation:
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PMID: 22226359 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Remyelination is a regenerative process in the central nervous system (CNS) that produces new myelin sheaths from adult stem cells. The decline in remyelination that occurs with advancing age poses a significant barrier to therapy in the CNS, particularly for long-term demyelinating diseases such as multiple sclerosis (MS). Here we show that remyelination of experimentally induced demyelination is enhanced in old mice exposed to a youthful systemic milieu through heterochronic parabiosis. Restored remyelination in old animals involves recruitment to the repairing lesions of blood-derived monocytes from the young parabiotic partner, and preventing this recruitment partially inhibits rejuvenation of remyelination. These data suggest that enhanced remyelinating activity requires both youthful monocytes and other factors, and that remyelination-enhancing therapies targeting endogenous cells can be effective throughout life. |
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Authors:
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Julia M Ruckh; Jing-Wei Zhao; Jennifer L Shadrach; Peter van Wijngaarden; Tata Nageswara Rao; Amy J Wagers; Robin J M Franklin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cell stem cell Volume: 10 ISSN: 1875-9777 ISO Abbreviation: Cell Stem Cell Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101311472 Medline TA: Cell Stem Cell Country: United States |
Other Details:
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Languages: eng Pagination: 96-103 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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MRC Centre for Stem Cell Biology and Regenerative Medicine & Cambridge Centre for Brain Repair & Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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