Document Detail

Rejection of Permacol mesh used in abdominal wall repair: a case report.
MedLine Citation:
PMID:  19750579     Owner:  NLM     Status:  MEDLINE    
Permacol mesh has shown promise when used in abdominal wall repair, especially in the presence of a contaminated surgical field. This biomaterial, derived from porcine dermis collagen, has proposed advantages over synthetic materials due to increased biocompatibility and reduced foreign body reaction within human tissues. However, we present a case report describing a patient who displayed rejection to a Permacol mesh when used in the repair of abdominal wound dehiscence following an emergency laparotomy. Review of the English language literature using PubMed and Medline, showed only two previously published cases of explantation of Permacol due to sepsis or wound breakdown. The authors believe this is the first case of severe foreign body reaction leading to rejection of Permacol. Both animal and human studies show conflicting evidence of biocompatibility. There are several reports of successful use of Permacol to repair complex incisional herniae or abdominal walls in the presence of significant contamination. It appears from the literature that Permacol is a promising material, but as we have demonstrated, it has the potential to evoke a foreign body reaction and rejection in certain subjects.
Franchesca T Wotton; Jacob A Akoh
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  15     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-14     Completed Date:  2009-09-30     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  4331-3     Citation Subset:  IM    
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MeSH Terms
Abdominal Wall / surgery*
Biocompatible Materials / adverse effects*
Collagen / adverse effects*,  immunology
Foreign-Body Reaction / diagnosis*,  epidemiology
Reg. No./Substance:
0/Biocompatible Materials; 0/Permacol; 9007-34-5/Collagen
Comment In:
World J Gastroenterol. 2010 Feb 7;16(5):657-8   [PMID:  20128039 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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