Document Detail

Reiter's syndrome associated with HLA-B51: a case report.
MedLine Citation:
PMID:  12635535     Owner:  NLM     Status:  MEDLINE    
A 32-year-old Japanese man developed polyarthritis with mild fever and conjunctivitis. Clinical assessment indicated non-specific arthritis, aseptic pyuria induced by infection with Chlamydia, and conjunctivitis. He was diagnosed with reactive arthritis (Reiter's syndrome). Serotyping of human leucocyte antigen (HLA) class I and II revealed positivity for B51(5), A2, A33(19), B44(12), Cw1, DR4 and DR6, but B27 was negative. He was treated with a combination of doxycycline, oral prednisolone, diclofenac sodium and salazosulphapyridine. Fever and arthralgia improved and he became negative for anti-Chlamydia immunoglobulin (Ig) A and IgG antibodies. HLA-B51 may be involved in the pathogenesis of Reiter's syndrome in this Japanese patient.
Y Taniguchi; N Yorioka; Y Kyuden; Y Asakimori
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  31     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2003 Jan-Feb
Date Detail:
Created Date:  2003-03-14     Completed Date:  2003-09-23     Revised Date:  2010-11-29    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  55-7     Citation Subset:  IM    
Division of Blood Purification, Hiroshima University Hospital, Hiroshima, Japan.
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MeSH Terms
Arthritis, Reactive / drug therapy,  immunology*,  radiography
Diclofenac / therapeutic use
Doxycycline / therapeutic use
HLA-B Antigens / immunology*
Prednisolone / therapeutic use
Sulfasalazine / therapeutic use
Reg. No./Substance:
0/HLA-B Antigens; 0/HLA-B51; 15307-86-5/Diclofenac; 50-24-8/Prednisolone; 564-25-0/Doxycycline; 599-79-1/Sulfasalazine

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