Document Detail


Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart.
MedLine Citation:
PMID:  18639539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Development of a functional organ requires the establishment of its proper size as well as the establishment of the relative proportions of its individual components. In the zebrafish heart, organ size and proportion depend heavily on the number of cells in each of its two major chambers, the ventricle and the atrium. Heart size and chamber proportionality are both affected in zebrafish fgf8 mutants. To determine when and how FGF signaling influences these characteristics, we examined the effect of temporally controlled pathway inhibition. During cardiac specification, reduction of FGF signaling inhibits formation of both ventricular and atrial cardiomyocytes, with a stronger impact on ventricular cells. After cardiomyocyte differentiation begins, reduction of FGF signaling can still result in a deficiency of ventricular cardiomyocytes. Consistent with two temporally distinct roles for FGF, we find that increased FGF signaling induces a cardiomyocyte surplus only before cardiac differentiation begins. Thus, FGF signaling first regulates heart size and chamber proportionality during cardiac specification and later refines ventricular proportion by regulating cell number after the onset of differentiation. Together, our data demonstrate that a single signaling pathway can act reiteratively to coordinate organ size and proportion.
Authors:
Sara R Marques; Yoonsung Lee; Kenneth D Poss; Deborah Yelon
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-07-04
Journal Detail:
Title:  Developmental biology     Volume:  321     ISSN:  1095-564X     ISO Abbreviation:  Dev. Biol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-15     Completed Date:  2008-10-27     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  397-406     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / physiology
Fibroblast Growth Factors / metabolism*
Fluorescent Antibody Technique
Heart / embryology*,  physiology
In Situ Hybridization
Myocytes, Cardiac / physiology
Organ Size
Pyrroles
Signal Transduction / physiology*
Transcription Factors / metabolism
Zebrafish / embryology*
Grant Support
ID/Acronym/Agency:
R01 HL069594/HL/NHLBI NIH HHS; R01 HL069594-01/HL/NHLBI NIH HHS; R01 HL069594-02/HL/NHLBI NIH HHS; R01 HL069594-03/HL/NHLBI NIH HHS; R01 HL069594-04/HL/NHLBI NIH HHS; R01 HL069594-05A1/HL/NHLBI NIH HHS; R01 HL069594-06/HL/NHLBI NIH HHS; R01 HL069594-07/HL/NHLBI NIH HHS; R01 HL081674/HL/NHLBI NIH HHS; R01 HL081674-03/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Pyrroles; 0/SU 5402; 0/Transcription Factors; 0/transcription factor PEA3; 62031-54-3/Fibroblast Growth Factors
Comments/Corrections

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