Document Detail

Reinvestigation of compound X, a suspected biotin intermediate: identification of N-formyl derivatives of biotin and dethiobiotin.
MedLine Citation:
PMID:  3531438     Owner:  NLM     Status:  MEDLINE    
Compound X, reported as an intermediate in the biosynthesis of biotin from dethiobiotin (DTB) (Biochem. Biophys. Res. Commun., 88, 312 (1979)), was found to contain N-formyl DTB and biotin. The methyl ester of N-formyl biotin was considered to be a product from the biotin, which was biosynthesized from DTB by resting cells of E. coli C 124, through treatment with diazomethane in the presence of a trace amount of formic acid after Dowex 1X2 column chromatography. NMR analysis revealed that biotin was formylated at 1'-N. N-Formylated DTB and biotin are new biotin derivatives.
M Osakai; K Tamura; Y Izumi; H Yamada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  32     ISSN:  0301-4800     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-11-19     Completed Date:  1986-11-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  279-86     Citation Subset:  IM    
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MeSH Terms
Biotin / analogs & derivatives*,  metabolism
Chromatography, Ion Exchange
Escherichia coli / analysis*
Reg. No./Substance:
15720-25-9/desthiobiotin; 334-88-3/Diazomethane; 58-85-5/Biotin

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