| Reinvestigation of the C5-acetamide sialic acid donor for α-selective sialylation: practical procedure under microfluidic conditions. | |
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MedLine Citation:
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PMID: 21879137 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Despite the previous literature describing the "low-to-modest" efficiency, the readily available C5-acetamide donor was reinvestigated for its use in α-sialylation under microfluidic conditions. The N-phenyltrifluoroacetimidate donor was efficiently mixed with an appropriate amount of TMSOTf to produce the α(2-6) and α(2-3)-sialylation products of galactose and glucosamine acceptors in excellent yields and with nearly perfect α-selectivity. |
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Authors:
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Yosuke Uchinashi; Masahiro Nagasaki; Jiazhou Zhou; Katsunori Tanaka; Koichi Fukase |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-30 |
Journal Detail:
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Title: Organic & biomolecular chemistry Volume: - ISSN: 1477-0539 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemistry, Graduate School of Science, Osaka University, Osaka, 560-0043, Japan. ktzenori@chem.sci.osaka-u.ac.jp koichi@chem.sci.osaka-u.ac.jp. |
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