Document Detail


Reinstatement of extinguished fear by an unextinguished conditional stimulus.
MedLine Citation:
PMID:  22586379     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Anxiety disorders are often treated using extinction-based exposure therapy, but relapse is common and can occur as a result of reinstatement, whereby an aversive "trigger" can reinstate extinguished fear. Animal models of reinstatement commonly utilize a Pavlovian fear conditioning procedure, in which subjects are first trained to fear a conditional stimulus (CS) by pairing it with an aversive unconditional stimulus (US), and then extinguished by repeated presentations of the CS alone. Reinstatement is typically induced by exposing subjects to an aversive US after extinction, but here we show that exposure to a non-extinguished CS can reinstate conditional fear responding to an extinguished CS, a phenomenon we refer to as "conditional reinstatement" (CRI). Rats were trained to fear two CSs (light and tone) and subsequently underwent extinction training to only one CS (counterbalanced). Presenting the unextinguished CS (but not a novel cue) immediately after extinction reinstated conditional fear responding to the extinguished CS in a test session given 24 h later. These findings indicate that reinstatement of extinguished fear can be triggered by exposure to conditional as well as unconditional aversive stimuli, and this may help to explain why relapse is common following clinical extinction therapy in humans. Further study of CRI using animal models may prove useful for developing refined extinction therapies that are more resistant to reinstatement.
Authors:
Lindsay R Halladay; Moriel Zelikowsky; Hugh T Blair; Michael S Fanselow
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Publication Detail:
Type:  Journal Article     Date:  2012-05-04
Journal Detail:
Title:  Frontiers in behavioral neuroscience     Volume:  6     ISSN:  1662-5153     ISO Abbreviation:  Front Behav Neurosci     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-15     Completed Date:  2012-10-02     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101477952     Medline TA:  Front Behav Neurosci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  18     Citation Subset:  -    
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
T32 NS058280/NS/NINDS NIH HHS

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