Document Detail

Reinke's edema and risk factors: clinical and histopathologic aspects.
MedLine Citation:
PMID:  11893974     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of this study was to evaluate retrospectively the distribution of histologic damage and its correlation with various risk factors in a group of patients affected by Reinke's edema. MATERIALS AND METHODS: The study subjects comprised 125 patients with bilateral Reinke's edema consecutively presenting at the Department of Otorhinolaryngology, "La Sapienza" University, Rome. The patients were divided into 4 groups according to Hellquist, Lundgren, and Olofsson's histologic classification and were then further categorized according to the number of cigarettes they smoked daily. Average exposure to cigarette smoke, occupation, habitual voice use, and gastroesophageal reflux were also considered. RESULTS: Fifty-two patients did not exhibit histologic lesions, 64 patients were histologically classified as Group 1 (epithelial hyperplasia and/or keratosis with or without mild dysplasia), and 6 patients exhibited moderate dysplasia (Group 2). In 3 patients, histologic examination showed evidence of unilateral carcinoma in situ (Group 3). Forty-four patients suffered recurrences within the first 2.5 years. Both daily cigarette consumption and duration of exposure to cigarette smoke were found to influence the severity of the histologic lesion. An association with gastroesophageal reflux was observed in 4 patients (3.2%). Prolonged vocal abuse did not prove to be a noteworthy factor in our study. CONCLUSIONS: The main risk factor for Reinke's edema and for its recurrence is tobacco use. Our study results showed that the clinical manifestation of this disease is related to the number of cigarettes smoked daily and the duration of exposure to smoke. Longer durations of exposure to cigarette smoke result in higher degrees of histologic damage.
Dario Marcotullio; Giuseppe Magliulo; Tiziana Pezone
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of otolaryngology     Volume:  23     ISSN:  0196-0709     ISO Abbreviation:  Am J Otolaryngol     Publication Date:    2002 Mar-Apr
Date Detail:
Created Date:  2002-03-14     Completed Date:  2002-05-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8000029     Medline TA:  Am J Otolaryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-4     Citation Subset:  IM    
Copyright Information:
Copyright 2002, Elsevier Science (USA). All rights reserved.)
Department of Otorhinolaryngology, "La Sapienza" University, Rome, Italy.
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MeSH Terms
Age Distribution
Biopsy, Needle
Cohort Studies
Laryngeal Edema / epidemiology*,  pathology*,  surgery
Laser Therapy
Middle Aged
Risk Factors
Sampling Studies
Sex Distribution
Smoking / adverse effects*
Vocal Cords / pathology,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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