| Reinforcement of an alternative behavior as a model of recovery and relapse in the rat. | |
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MedLine Citation:
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PMID: 23274846 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A preclinical model that includes measures of alternative behavior and drug-seeking could improve our understanding of the processes involved in successful recovery; however current preclinical models of relapse do not measure alternative behavior. We assessed the persistence of food-maintained responding and the resumption of ethanol-maintained responding after ethanol-maintained responding was reduced by changing the response requirement for concurrently available food. Ethanol (10% w/v) was always available following 5 responses (FR5). A 16kHz tone indicating food delivery followed 150 responses (FR150) resulted in ethanol-predominate responding and substantial amounts of ethanol were earned (0.47g/kg per 30-min session) and consumed. An 8kHz tone indicating food delivery followed 5 responses (FR5) for 1, 2, 4, or 16 consecutive sessions reduced ethanol-maintained responding despite unchanged ethanol availability. Ethanol-maintained responding resumed upon subsequent presentation of the 16kHz tone. However, more responses occurred on the food lever before 5 responses occurred on the ethanol lever as the number of preceding FR5 food sessions increased. These results suggest that alternative reinforcement may reduce control by discriminative stimuli that occasion ethanol-seeking and is consistent with the risk of relapse declining with longer periods of recovery because of the strength of alternative behavior. |
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Authors:
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Brett C Ginsburg; R J Lamb |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-27 |
Journal Detail:
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Title: Behavioural processes Volume: - ISSN: 1872-8308 ISO Abbreviation: Behav. Processes Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703854 Medline TA: Behav Processes Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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Departments of Psychiatry and Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229. Electronic address: ginsburg@uthscsa.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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