Document Detail


Reinforcement of an alternative behavior as a model of recovery and relapse in the rat.
MedLine Citation:
PMID:  23274846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A preclinical model that includes measures of alternative behavior and drug-seeking could improve our understanding of the processes involved in successful recovery; however current preclinical models of relapse do not measure alternative behavior. We assessed the persistence of food-maintained responding and the resumption of ethanol-maintained responding after ethanol-maintained responding was reduced by changing the response requirement for concurrently available food. Ethanol (10%, w/v) was always available following 5 responses (FR5). A 16 kHz tone indicating food delivery followed 150 responses (FR150) resulted in ethanol-predominate responding and substantial amounts of ethanol were earned (0.47 g/kg per 30-min session) and consumed. An 8 kHz tone indicating food delivery followed 5 responses (FR5) for 1, 2, 4, or 16 consecutive sessions reduced ethanol-maintained responding despite unchanged ethanol availability. Ethanol-maintained responding resumed upon subsequent presentation of the 16 kHz tone. However, more responses occurred on the food lever before 5 responses occurred on the ethanol lever as the number of preceding FR5 food sessions increased. These results suggest that alternative reinforcement may reduce control by discriminative stimuli that occasion ethanol-seeking and is consistent with the risk of relapse declining with longer periods of recovery because of the strengthening of alternative behavior.
Authors:
Brett C Ginsburg; R J Lamb
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-12-27
Journal Detail:
Title:  Behavioural processes     Volume:  94     ISSN:  1872-8308     ISO Abbreviation:  Behav. Processes     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-19     Completed Date:  2013-09-17     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  7703854     Medline TA:  Behav Processes     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  60-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Alcoholism / physiopathology,  psychology*
Analysis of Variance
Animals
Behavior, Animal / drug effects*
Disease Models, Animal
Drug-Seeking Behavior*
Ethanol / blood,  pharmacology*
Extinction, Psychological*
Male
Rats
Rats, Inbred Lew
Recurrence*
Grant Support
ID/Acronym/Agency:
AA012337/AA/NIAAA NIH HHS; AA016987/AA/NIAAA NIH HHS; R01 AA012337/AA/NIAAA NIH HHS; R01 AA016987/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
3K9958V90M/Ethanol
Comments/Corrections

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