| Rehabilitative therapy of short bowel syndrome: experimental study and clinical trial. | |
| | |
MedLine Citation:
|
PMID: 11832109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To investigate the effect of growth hormone on proliferative activity of the residual small intestinal mucosa after massive small intestinal resection and to evaluate the clinical efficacy of bowel rehabilitative therapy for short bowel syndrome. METHODS: Small intestinal mucosa proliferative activity were compared in rats from control group (sham operation), short bowel group (80% small bowel resection) and growth hormone treatment group (80% small bowel resection + growth hormone 1 U x kg(-1) x d(-1) for 28 days) with the aid of histology image analysis, flow cytometric assay, immunohistochemistry analysis and RT-PCR assay. The nutritional status, D-xylose absorption and stool nitrogen output were observed in 9 consecutive parenteral nutrition dependent patients with short bowel syndrome after intestinal rehabilitative therapy (growth hormone 8 - 12 U x kg(-1) x d(-1) im + glutamine 0.6 g x kg(-1) x d(-1) iv + special diet) for 21 continuous days. RESULTS: Growth hormone administration significantly increased rat small intestinal mucosal villous height, mucosal thickness, proliferative index, and the expression of proliferating cell nuclear antigen and c-jun mRNA. Rehabilitative therapy increased the body weight, serum total protein and album in concentrations in patients. Their D-xylose absorption indices increased and fecal nitrogen losses decreased. Follow-up data showed that 6 of the 9 patients sustained on enteral nutrition. CONCLUSION: Growth hormone enhances the proliferative activity of the mucosal epithelium and bowel rehabilitative therapy may benefit the patients with short bowel syndrome. |
| | |
Authors:
|
N Li; W Zhu; F Guo; J Ren; Y Li; X Wang; J Li |
Related Documents
:
|
15590889 - Involvement of mrp2 in hepatic and intestinal disposition of dinitrophenyl-s-glutathion... 12479649 - Potato glycoalkaloids adversely affect intestinal permeability and aggravate inflammato... 20222989 - Dietary fat and bile juice, but not obesity, are responsible for the increase in small ... 4035669 - Effects of feeding stannous chloride on different parts of the gastrointestinal tract o... 8260559 - Effect of preclosure colostrum intake on the development of the intestinal epithelium o... 8044999 - Hplc determination of polyethylene glycol 400 in urine: oligomeric profile in healthy a... 11777749 - Influence of transcutol cg on the skin accumulation and transdermal permeation of ultra... 11420779 - Unbalanced diet to lower serum cholesterol level is a risk factor for postmenopausal os... 8821459 - Serum cholesterol and ischaemic heart disease. |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: Zhonghua wai ke za zhi [Chinese journal of surgery] Volume: 38 ISSN: 0529-5815 ISO Abbreviation: Zhonghua Wai Ke Za Zhi Publication Date: 2000 Aug |
Date Detail:
|
Created Date: 2002-02-08 Completed Date: 2005-01-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0153611 Medline TA: Zhonghua Wai Ke Za Zhi Country: China |
Other Details:
|
Languages: eng Pagination: 565-9 Citation Subset: IM |
Affiliation:
|
Institute of General Surgery, Nanjing General Hospital of People's Liberation Army, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Animals Cell Division / drug effects Child Combined Modality Therapy Follow-Up Studies Glutamine / therapeutic use* Growth Hormone / therapeutic use* Humans Injections, Intramuscular Intestinal Mucosa / cytology, drug effects* Intestine, Small Middle Aged Parenteral Nutrition, Total Rats Rats, Sprague-Dawley Short Bowel Syndrome / drug therapy, rehabilitation* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
56-85-9/Glutamine; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The invasive ability of bladder cancer
Next Document: Results: of 2000 kidney transplantations