Document Detail

Rehabilitation of patients with congestive heart failure with or without beta-blockade therapy.
MedLine Citation:
PMID:  11561225     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Management of heart failure includes beta-blockade (betaB) therapy and cardiac rehabilitation. The aim of this study was to compare the exercise training response of patients with congestive heart failure (CHF) receiving betaB therapy with that of patients not receiving treatment. METHODS AND RESULTS: Thirty-four consecutive patients with CHF were included in a 4-week training program at their ventilatory threshold (VT); 6 patients received betaB treatment and 18 did not. The patients underwent a cardiopulmonary exercise test before and after training. Oxygen uptake (VO(2)) at peak exercise and at VT increased in both groups (P < or =.0001) without any significant differences between the groups. The same results were found after adjustment to ejection fraction and VO(2) at the start of the training program. There was no difference in VT improvement, measured as a percentage of utilization of maximal oxygen uptake, between the groups. After training, heart rate and ventilation decreased (P < or =.0001) at submaximal levels in both groups without significant differences between the groups. CONCLUSIONS: betaB therapy does not impair functional improvement induced by a rehabilitation program in patients with CHF. betaB therapy does not interfere with exercise training prescription if patient exercise evaluations are made at the time of therapeutic intake.
D Curnier; M Galinier; A Pathak; J Fourcade; M Bousquet; J M Senard; J M Fauvel; J P Bounhoure; J L Montastruc
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  7     ISSN:  1071-9164     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-18     Completed Date:  2001-10-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  241-8     Citation Subset:  IM    
INSERM Unité 317, Laboratoire de Pharmacologie Clinique et Expérimentale, Faculté de Médecine, Toulouse, France.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Case-Control Studies
Exercise Test
Exercise Therapy*
Heart Failure / drug therapy*,  rehabilitation*
Heart Rate
Middle Aged
Oxygen Consumption
Prospective Studies
Pulmonary Ventilation
Time Factors
Reg. No./Substance:
0/Adrenergic beta-Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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