Document Detail

Regurgitant volume in aortic regurgitation from a parameter estimation procedure.
MedLine Citation:
PMID:  8005885     Owner:  NLM     Status:  MEDLINE    
The regurgitant volume and regurgitant orifice area as well as total peripheral resistance and arterial compliance were estimated in a cardiovascular hydromechanical simulator and in 10 patients with aortic regurgitation. A parameter estimation procedure based on a simple model of the cardiovascular system, Doppler measurements of the regurgitant jet, aortic systolic flow, and systolic and diastolic blood pressures was used. In the cardiovascular simulator the estimated regurgitant orifice area was compared with the size of a hole in the disk of a mechanical aortic valve. In the patients the regurgitant fraction was compared with semiquantitative grading from echocardiography routinely performed in our laboratory. In the hydromechanical simulator, the estimated regurgitant orifice area of 26.5 +/- 3.5 (SD) mm2 (n = 9) was not different from the true value of 24 mm2. In the patients there was a fair relationship between the estimated regurgitant fraction and the semiquantitative grading. The estimated regurgitant orifice areas varied between 1.6 and 31.2 mm2. The estimated mean values of total peripheral resistance and arterial compliance were 1.67 +/- 0.55 and 1.30 +/- 0.42 ml/mmHg, respectively.
S A Slørdahl; H F Kuecherer; J E Solbakken; H Piene; B A Angelsen; N B Schiller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  76     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-15     Completed Date:  1994-07-15     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1378-83     Citation Subset:  IM    
Adult Echocardiography Laboratory/Cardiovascular Research Institute, University of California, San Francisco 94143-0214.
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MeSH Terms
Aged, 80 and over
Aortic Valve / physiopathology
Aortic Valve Insufficiency / physiopathology*
Blood Pressure / physiology
Cardiac Output / physiology
Chronic Disease
Diastole / physiology
Echocardiography, Doppler
Heart Rate / physiology
Middle Aged
Models, Biological
Regional Blood Flow / physiology
Systole / physiology
Vascular Resistance / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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