Document Detail


Regulatory use of computational toxicology tools and databases at the United States food and drug administration's office of food additive safety.
MedLine Citation:
PMID:  20491519     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Over 10 years ago, the Office of Food Additive Safety (OFAS) in the FDA's Center for Food Safety and Applied Nutrition implemented the formal use of structure-activity relationship analysis and quantitative structure-activity relationship (QSAR) analysis in the premarket review of food-contact substances. More recently, OFAS has implemented the use of multiple QSAR software packages and has begun investigating the use of metabolism data and metabolism predictive models in our QSAR evaluations of food-contact substances. In this article, we provide an overview of the programs used in OFAS as well as a perspective on how to apply multiple QSAR tools in the review process of a new food-contact substance.
Authors:
Kirk B Arvidson; Ronald Chanderbhan; Kristi Muldoon-Jacobs; Julie Mayer; Adejoke Ogungbesan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on drug metabolism & toxicology     Volume:  6     ISSN:  1744-7607     ISO Abbreviation:  Expert Opin Drug Metab Toxicol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101228422     Medline TA:  Expert Opin Drug Metab Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  793-6     Citation Subset:  IM    
Affiliation:
US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, HFS-275, 5100 Paint Branch Parkway, College Park, MD 20740, USA. Kirk.Arvidson@fda.hhs.gov
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