| Regulatory use of computational toxicology tools and databases at the United States food and drug administration's office of food additive safety. | |
| | |
MedLine Citation:
|
PMID: 20491519 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Over 10 years ago, the Office of Food Additive Safety (OFAS) in the FDA's Center for Food Safety and Applied Nutrition implemented the formal use of structure-activity relationship analysis and quantitative structure-activity relationship (QSAR) analysis in the premarket review of food-contact substances. More recently, OFAS has implemented the use of multiple QSAR software packages and has begun investigating the use of metabolism data and metabolism predictive models in our QSAR evaluations of food-contact substances. In this article, we provide an overview of the programs used in OFAS as well as a perspective on how to apply multiple QSAR tools in the review process of a new food-contact substance. |
| | |
Authors:
|
Kirk B Arvidson; Ronald Chanderbhan; Kristi Muldoon-Jacobs; Julie Mayer; Adejoke Ogungbesan |
Related Documents
:
|
18159469 - Food safety and foodborne disease in 21st century homes. 12870769 - Managing the risk of staphylococcal food poisoning from cream-filled baked goods to mee... 16542769 - Safety evaluation of phytosterol-esters. part 9: results of a european post-launch moni... 11548529 - Animal identification: links to food safety. 15808359 - Lay and expert perceptions of zoonotic risks: understanding conflicting perspectives in... 17095119 - Food risk perceptions, gender, and individual differences in avoidance and approach mot... 21545829 - Mechanisms of intake induction of a low-nutritious food in sheep (ovis aries). 14564939 - The foodlet vehicle designed for and used in the iris i intervention. 8577309 - A simple colony-blot method for identification of listeria in food samples. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Expert opinion on drug metabolism & toxicology Volume: 6 ISSN: 1744-7607 ISO Abbreviation: Expert Opin Drug Metab Toxicol Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-06-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101228422 Medline TA: Expert Opin Drug Metab Toxicol Country: England |
Other Details:
|
Languages: eng Pagination: 793-6 Citation Subset: IM |
Affiliation:
|
US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, HFS-275, 5100 Paint Branch Parkway, College Park, MD 20740, USA. Kirk.Arvidson@fda.hhs.gov |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Complementary and alternative medicine use by osteoporotic patients in Australia (CAMEO-A): a prospe...
Next Document: Antioxidant properties of fullerenol C(60)(OH)(24) in rat kidneys, testes, and lungs treated with do...