Document Detail

Regulatory role of nitric oxide over extracellular taurine in the hippocampus of freely moving rats.
MedLine Citation:
PMID:  15003279     Owner:  NLM     Status:  MEDLINE    
We have studied the effects of drugs which manipulate nitric oxide (NO) levels as well the effect of N-methyl-d-aspartate (NMDA) infusion on extracellular taurine in rat hippocampus using in vivo microdialysis. The NO donor S-nitroso-N-acetylpenicillamine (SNAP) increased dialysate taurine in a concentration-dependent manner, and this effect was blocked by the inhibitor of soluble guanylate cyclase1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ). NMDA (100 microM) increased hippocampal taurine release, an effect that was reversed by the NMDA receptor antagonist 2-amino-5-phosphonopentanoic acid (AP5; 10 microM). The non-selective nitric oxide synthase (NOS) inhibitor N-nitro-l-arginine methyl ester (L-NAME; 100 microM and 1.0 mM) increased extracellular taurine in a concentration-dependent manner while 7-nitroindazole (7-NI), a relatively selective neuronal NOS (nNOS) inhibitor, at the same concentrations decreased extracellular taurine. L-NAME (1.0 mM) infused prior to NMDA did not alter the effect of NMDA on extracellular taurine having an effect essentially identical to that seen with L-NAME infused alone. In contrast, when 7-NI was infused for 30 min prior to NMDA, taurine levels were no longer increased above basal. This suggests to us that taurine efflux is mediated by two different mechanisms: an NMDA-evoked, 7-NI-sensitive pathway which may be dependent on cyclic guanosine monophosphate formation, and an L-NAME-modulated mechanism which presumably involves other members of the NOS group of enzymes than nNOS alone.
Jo Watts; Joanna Segieth; Brian Pearce; Peter S Whitton
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  357     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-08     Completed Date:  2004-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  179-82     Citation Subset:  IM    
Department of Pharmacology, The School of Pharmacy, London WC1N 1AX, UK.
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MeSH Terms
2-Amino-5-phosphonovalerate / pharmacology
Dose-Response Relationship, Drug
Drug Interactions
Enzyme Inhibitors / pharmacology
Excitatory Amino Acid Agonists / pharmacology
Excitatory Amino Acid Antagonists / pharmacology
Extracellular Space / drug effects,  metabolism*
Hippocampus / drug effects,  metabolism*,  physiology
Microdialysis / methods
N-Methylaspartate / pharmacology
Nitric Oxide / metabolism,  physiology*
Nitric Oxide Donors / pharmacology
Penicillamine / analogs & derivatives*,  pharmacology
Rats, Wistar
Taurine / metabolism*
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Excitatory Amino Acid Agonists; 0/Excitatory Amino Acid Antagonists; 0/Nitric Oxide Donors; 0/S-nitro-N-acetylpenicillamine; 10102-43-9/Nitric Oxide; 107-35-7/Taurine; 52-67-5/Penicillamine; 6384-92-5/N-Methylaspartate; 76726-92-6/2-Amino-5-phosphonovalerate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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