| Regulatory role of cathepsin D in apoptosis. | |
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MedLine Citation:
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PMID: 17951163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cathepsin D (CTSD, EC 3.4.23.5) is well known aspartyl protease. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. Cathepsin D can either induce apoptosis in presence of cytotoxic factors, but in certain studies an inhibitory role in apoptosis was also reviewed. Detailed review of involvement of cathepsin D in cell apoptosis is a purpose of this paper. |
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Authors:
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Alina Minarowska; Lukasz Minarowski; Alicja Karwowska; Marek Gacko |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society Volume: 45 ISSN: 0239-8508 ISO Abbreviation: Folia Histochem. Cytobiol. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-10-22 Completed Date: 2008-04-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502651 Medline TA: Folia Histochem Cytobiol Country: Poland |
Other Details:
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Languages: eng Pagination: 159-63 Citation Subset: IM |
Affiliation:
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3rd Department of Children's Diseases, Medical University of Białystok, Poland. minar@mp.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology* Cathepsin D / physiology* Humans |
| Chemical | |
Reg. No./Substance:
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EC 3.4.23.5/Cathepsin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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