| Regulatory properties of the intestinal microbiome effecting the development and treatment of diabetes. | |
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MedLine Citation:
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PMID: 22357099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: The microbiome continues to demonstrate an important role in immune and metabolic programming. This review will focus on the mechanistic implications of recent findings for diabetes pathogenesis and treatment. RECENT FINDINGS: Multiple techniques are developing to specify the microbiome. At the same time, new insights have emerged into local interactions of microbial products with human development. New findings demonstrate that key bacteria and their products result in the programming of diabetes-modulating Th17 and regulatory T lymphocytes within and outside the intestine. The role of the bacterial metagenome in programming human metabolism has also revealed new insights. In turn, these findings suggest a framework in which the microbiome may be modified to change the course of diabetes. SUMMARY: The microbiome is a key regulator of metabolism and immunity. Specific bacteria and their secreted products are now known to program Th17 and regulatory T-cell development, which may change the course of diabetes. Bacterial genomics are demonstrating important, modifiable roles of bacterial gene products in metabolism. Further understanding of this symbiotic relationship will provide new avenues for intervention in diabetes. |
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Authors:
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Joann Romano-Keeler; Jöern-Hendrik Weitkamp; Daniel J Moore |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in endocrinology, diabetes, and obesity Volume: 19 ISSN: 1752-2978 ISO Abbreviation: Curr Opin Endocrinol Diabetes Obes Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-02-29 Completed Date: 2012-06-25 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 101308636 Medline TA: Curr Opin Endocrinol Diabetes Obes Country: England |
Other Details:
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Languages: eng Pagination: 73-80 Citation Subset: IM |
Affiliation:
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Mildred Stahlman Division of Neonatology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptive Immunity
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immunology* Diabetes Mellitus, Type 1 / immunology*, microbiology Diabetes Mellitus, Type 2 / immunology*, microbiology Female Humans Intestines / microbiology* Male Metagenome / immunology* T-Lymphocytes, Regulatory |
| Grant Support | |
ID/Acronym/Agency:
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5P60DK20593-33/DK/NIDDK NIH HHS; K08 DK090146/DK/NIDDK NIH HHS; K08 HD061607/HD/NICHD NIH HHS; K08DK090146/DK/NIDDK NIH HHS; K08HD061607/HD/NICHD NIH HHS; KL2 RR024977/RR/NCRR NIH HHS; KL2 TR000446/TR/NCATS NIH HHS; P30DK058404/DK/NIDDK NIH HHS; T32HD068256/HD/NICHD NIH HHS; TL1 RR024978/RR/NCRR NIH HHS; TL1 TR000447/TR/NCATS NIH HHS; UL1 RR024975/RR/NCRR NIH HHS; UL1 RR024975-01/RR/NCRR NIH HHS; UL1 TR000445/TR/NCATS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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