| Regulatory peptides in endocrine cells and autonomic nerves: electron immunocytochemistry. | |
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MedLine Citation:
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PMID: 6947395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Advances in immunocytochemistry, particularly at the electron microscope level, have enabled us to establish further details of the ultrastructural appearance of endocrine cells and autonomic nerves of the gastrointestinal tract. Its contribution can be summarised as follows: a)validation of previously recognised endocrine cell types. b) Recognition of sub-groups within endocrine cells and autonomic nerve cell types previously included within one single type (e.g. D1 cells and p-type autonomic nerves). c) Discrimination of molecular forms now known to be stored in morphologically distinguishable secretory granules or parts thereof (e.g. pro-glucagon and glucagon in A cells and gut and antral gastrin-producing cells). Advances in the techniques and the accurate quantification of the end products will enable us to recognise changes in gastrointestinal tract diseases in man. |
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Authors:
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J M Polak; A M Buchan; L Probert; F Tapia; J de Mey; S R Bloom |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of gastroenterology. Supplement Volume: 70 ISSN: 0085-5928 ISO Abbreviation: Scand. J. Gastroenterol. Suppl. Publication Date: 1981 |
Date Detail:
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Created Date: 1982-02-22 Completed Date: 1982-02-22 Revised Date: 2008-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0437034 Medline TA: Scand J Gastroenterol Suppl Country: NORWAY |
Other Details:
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Languages: eng Pagination: 11-23 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autonomic Nervous System / analysis, anatomy & histology* Cytoplasmic Granules / analysis Digestive System / innervation* Gastrins / analysis Gastrointestinal Hormones / analysis* Glucagon / analysis Humans Immunochemistry Microscopy, Electron Proglucagon Protein Precursors / analysis |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 0/Gastrointestinal Hormones; 0/Protein Precursors; 55963-74-1/Proglucagon; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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