Document Detail

Regulatory peptides in endocrine cells and autonomic nerves: electron immunocytochemistry.
MedLine Citation:
PMID:  6947395     Owner:  NLM     Status:  MEDLINE    
Advances in immunocytochemistry, particularly at the electron microscope level, have enabled us to establish further details of the ultrastructural appearance of endocrine cells and autonomic nerves of the gastrointestinal tract. Its contribution can be summarised as follows: a)validation of previously recognised endocrine cell types. b) Recognition of sub-groups within endocrine cells and autonomic nerve cell types previously included within one single type (e.g. D1 cells and p-type autonomic nerves). c) Discrimination of molecular forms now known to be stored in morphologically distinguishable secretory granules or parts thereof (e.g. pro-glucagon and glucagon in A cells and gut and antral gastrin-producing cells). Advances in the techniques and the accurate quantification of the end products will enable us to recognise changes in gastrointestinal tract diseases in man.
J M Polak; A M Buchan; L Probert; F Tapia; J de Mey; S R Bloom
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology. Supplement     Volume:  70     ISSN:  0085-5928     ISO Abbreviation:  Scand. J. Gastroenterol. Suppl.     Publication Date:  1981  
Date Detail:
Created Date:  1982-02-22     Completed Date:  1982-02-22     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0437034     Medline TA:  Scand J Gastroenterol Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  11-23     Citation Subset:  IM    
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MeSH Terms
Autonomic Nervous System / analysis,  anatomy & histology*
Cytoplasmic Granules / analysis
Digestive System / innervation*
Gastrins / analysis
Gastrointestinal Hormones / analysis*
Glucagon / analysis
Microscopy, Electron
Protein Precursors / analysis
Reg. No./Substance:
0/Gastrins; 0/Gastrointestinal Hormones; 0/Protein Precursors; 55963-74-1/Proglucagon; 9007-92-5/Glucagon

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