| Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment. | |
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MedLine Citation:
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PMID: 23264918 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We identified novel mechanisms whereby TIM-3 suppresses innate immunity as induced by nucleic acids. Interaction of TIM-3 with HMGB1 inhibits the recruitment of nucleic acids to the endosomal compartment of dendritic cells, impairing the transduction of innate immune signals. Thus, TIM-3 is an effective target for enhancing the immunogenicity of nucleic acids in the context of cancer therapy. |
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Authors:
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Masahisa Jinushi |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Oncoimmunology Volume: 1 ISSN: 2162-4011 ISO Abbreviation: Oncoimmunology Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101570526 Medline TA: Oncoimmunology Country: - |
Other Details:
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Languages: ENG Pagination: 1632-1634 Citation Subset: - |
Affiliation:
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Research Center for Infection-Associated Cancer; Institute for Genetic Medicine; Hokkaido University; Sapporo, Japan. |
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