Document Detail


Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment.
MedLine Citation:
PMID:  23264918     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We identified novel mechanisms whereby TIM-3 suppresses innate immunity as induced by nucleic acids. Interaction of TIM-3 with HMGB1 inhibits the recruitment of nucleic acids to the endosomal compartment of dendritic cells, impairing the transduction of innate immune signals. Thus, TIM-3 is an effective target for enhancing the immunogenicity of nucleic acids in the context of cancer therapy.
Authors:
Masahisa Jinushi
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Oncoimmunology     Volume:  1     ISSN:  2162-4011     ISO Abbreviation:  Oncoimmunology     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101570526     Medline TA:  Oncoimmunology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1632-1634     Citation Subset:  -    
Affiliation:
Research Center for Infection-Associated Cancer; Institute for Genetic Medicine; Hokkaido University; Sapporo, Japan.
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