Document Detail

Regulatory mechanisms in melatonin biosynthesis in retina.
MedLine Citation:
PMID:  1304316     Owner:  NLM     Status:  MEDLINE    
The vertebrate retina produces melatonin in a light-dependent rhythmic fashion, synchronized with, but independent from the rhythm of the hormone formation in the pineal gland. This review summarizes the current status of our knowledge on regulatory mechanisms involved in controlling the retinal melatonin biosynthesis. Special emphasis is given to the role and mode of action of dopamine and GABA, two established retinal neurotransmitters, as well as that of second messengers (cyclic AMP, calcium ions). Comparisons are made between lower vertebrates and mammals.
J B Zawilska; J Z Nowak
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Neurochemistry international     Volume:  20     ISSN:  0197-0186     ISO Abbreviation:  Neurochem. Int.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1993-07-07     Completed Date:  1993-07-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8006959     Medline TA:  Neurochem Int     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  23-36     Citation Subset:  IM    
Department of Pharmacodynamics, Medical University, Lodz, Poland.
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MeSH Terms
Acetylserotonin O-Methyltransferase / metabolism
Arylamine N-Acetyltransferase / metabolism
Circadian Rhythm
Melatonin / biosynthesis,  metabolism*
Photoreceptor Cells / metabolism
Retina / metabolism*
Serotonin / metabolism
Reg. No./Substance:
50-67-9/Serotonin; 73-31-4/Melatonin; EC O-Methyltransferase; EC N-Acetyltransferase

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