Document Detail


Regulatory mechanisms for the expression and activity of platelet-derived growth factor receptor.
MedLine Citation:
PMID:  14515146     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PDGF is one of the most potent serum mitogens, and the signalling mechanism by way of its receptor tyrosine-kinase has been extensively studied since its first purification in 1979. The identification of homology between the simian sarcoma virus oncogene, v-sis, and the B-chain of PDGF, as well as the frequent over-expression of both the ligands and receptors in various tumours and stroma led to the proposal of the PDGF-mediated autocrine and paracrine hypothesis. Consistent with the important roles of PDGF in the growth and survival of cells, the expression and activity of PDGF receptors are tightly controlled by both positive and negative feedback mechanisms at different levels. The deregulation of the control system can result in serious pathological conditions such as chronic inflammation and tumours. Understanding the molecular mechanisms for the regulatory system and the signalling pathway of PDGF is essential in order to find effective therapies in the diseases where PDGF is involved.
Authors:
Keiko Funa; Hidetaka Uramoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta biochimica Polonica     Volume:  50     ISSN:  0001-527X     ISO Abbreviation:  Acta Biochim. Pol.     Publication Date:  2003  
Date Detail:
Created Date:  2003-09-29     Completed Date:  2004-08-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  14520300R     Medline TA:  Acta Biochim Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  647-58     Citation Subset:  IM    
Affiliation:
Institute of Anatomy and Cell Biology, Göteborg University, Box 420, SE-405 30 Gothenburg, Sweden. keiko.funa@anatcell.gu.se
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Division / physiology
Cell Survival / physiology
Cell Transformation, Neoplastic / metabolism*
Dimerization
Humans
Oncogene Proteins v-sis / genetics*
Phosphorylation
Platelet-Derived Growth Factor / genetics,  metabolism*
Receptors, Platelet-Derived Growth Factor / genetics,  metabolism*
Signal Transduction / physiology
Chemical
Reg. No./Substance:
0/Oncogene Proteins v-sis; 0/Platelet-Derived Growth Factor; EC 2.7.10.1/Receptors, Platelet-Derived Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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