| Regulatory mechanisms of blood lactate production during exercise in man. | |
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MedLine Citation:
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PMID: 2638924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During cycloergometric exercise at progressively increasing loads, blood lactate concentration increased about 12-fold. Pyruvate concentration decreased initially (for loads of 50-75 W), increased with loads of 75 to 125 W and then decreased again until the end of exercise. The malate concentration increased abruptly between 50 and 75 W, followed by a slow decline; citrate increased about nine-fold as the exercise load was increased to 125 W and then fell sharply. Thus, the production of lactate during low-intensity exercise seems to occur by the "mass-action effect" caused by enhanced glycolysis, whereas with moderate loads the glycolysis rate is very much reduced and most of the lactate production seems to involve the action of the malate-aspartate shuttle. For high-intensity exercise, both mechanisms appear to participate in lactate production. |
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Authors:
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M S Palma; E Kokubun; C Y Sibuya; J W Santos; P M Freire |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 22 ISSN: 0100-879X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 1989 |
Date Detail:
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Created Date: 1990-08-13 Completed Date: 1990-08-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: BRAZIL |
Other Details:
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Languages: eng Pagination: 1329-32 Citation Subset: IM |
Affiliation:
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Departamento de Educação Física, Universidade Estadual Paulista, Rio Claro, SP, Brasil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, High Pressure Liquid Citrates / blood Exercise* Humans Lactates / blood*, metabolism Malates / blood Male Muscles / metabolism Oxygen Consumption Pyruvates / blood |
| Chemical | |
Reg. No./Substance:
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0/Citrates; 0/Lactates; 0/Malates; 0/Pyruvates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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