Document Detail

Regulatory mechanisms of blood lactate production during exercise in man.
MedLine Citation:
PMID:  2638924     Owner:  NLM     Status:  MEDLINE    
During cycloergometric exercise at progressively increasing loads, blood lactate concentration increased about 12-fold. Pyruvate concentration decreased initially (for loads of 50-75 W), increased with loads of 75 to 125 W and then decreased again until the end of exercise. The malate concentration increased abruptly between 50 and 75 W, followed by a slow decline; citrate increased about nine-fold as the exercise load was increased to 125 W and then fell sharply. Thus, the production of lactate during low-intensity exercise seems to occur by the "mass-action effect" caused by enhanced glycolysis, whereas with moderate loads the glycolysis rate is very much reduced and most of the lactate production seems to involve the action of the malate-aspartate shuttle. For high-intensity exercise, both mechanisms appear to participate in lactate production.
M S Palma; E Kokubun; C Y Sibuya; J W Santos; P M Freire
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  22     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  1989  
Date Detail:
Created Date:  1990-08-13     Completed Date:  1990-08-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  1329-32     Citation Subset:  IM    
Departamento de Educação Física, Universidade Estadual Paulista, Rio Claro, SP, Brasil.
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MeSH Terms
Chromatography, High Pressure Liquid
Citrates / blood
Lactates / blood*,  metabolism
Malates / blood
Muscles / metabolism
Oxygen Consumption
Pyruvates / blood
Reg. No./Substance:
0/Citrates; 0/Lactates; 0/Malates; 0/Pyruvates

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