Document Detail

Regulatory mechanism of osteoclastogenesis by RANKL and Wnt signals.
MedLine Citation:
PMID:  21196156     Owner:  NLM     Status:  MEDLINE    
Osteoclasts develop from monocyte-macrophage lineage cells under the regulation of osteoblasts. Osteoblasts express two cytokines essential for osteoclastogenesis, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-KappaB ligand (RANKL). Osteoblasts also produce osteoprotegerin (OPG), a decoy receptor for RANKL, which inhibits the interaction between RANKL and RANK, a receptor of RANKL. Bone resorption-stimulating factors act on osteoblasts to regulate RANKL and OPG expression. Nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) is a master transcription factor for osteoclast differentiation. The immunoreceptor tyrosine-based activation motif (ITAM)-mediated signal was discovered as a co-stimulatory signal in RANKL-induced osteoclastogenesis. Wnt proteins activate two pathways: beta-catenin-dependent canonical and beta-catenin-independent noncanonical pathways. Wnt proteins promote differentiation of osteoblasts through the canonical pathway. The canonical pathway in osteoblasts also suppresses osteoclastogenesis through up-regulation of OPG expression and down-regulation of RANKL expression. In contrast, activation of the noncanonical pathway in osteoclast precursors enhances RANKL-induced osteoclastic differentiation. Thus, Wnt signals in osteoblasts and osteoclast precursors play important roles in osteoclastogenesis. This review summarizes the regulatory mechanism of osteoclastogenesis by RANKL and Wnt signals.
Naoyuki Takahashi; Kazuhiro Maeda; Akihiro Ishihara; Shunsuke Uehara; Yasuhiro Kobayashi
Related Documents :
21368136 - Multiple coregulatory control of tyrosine hydroxylase gene transcription.
21224066 - Enhanced epidermal growth factor, hepatocyte growth factor, and vascular endothelial gr...
9710616 - Gata-dependent expression of the interleukin-1 receptor-related t1 gene in mast cells.
9405456 - Finkel-biskis-reilly osteosarcoma virus v-fos inhibits adipogenesis and both the activi...
16675706 - Oncogenic k-ras cooperates with pml-rar alpha to induce an acute promyelocytic leukemia...
23951196 - Sirt1 inhibits akt2-mediated porcine adipogenesis potentially by direct protein-protein...
Publication Detail:
Type:  Journal Article; Review     Date:  2011-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  16     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2011  
Date Detail:
Created Date:  2011-01-03     Completed Date:  2011-04-21     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-30     Citation Subset:  IM    
Institute for Oral Science, Matsumoto Dental University, 1780 Gobara, Hiro-oka, Shiojiri, Nagano 399-0781, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adaptor Proteins, Signal Transducing
Bone Resorption / physiopathology
Cell Differentiation
Macrophage Colony-Stimulating Factor / metabolism
Membrane Proteins / physiology
NFATC Transcription Factors / physiology
Osteoclasts / cytology,  physiology*
RANK Ligand / physiology*
Signal Transduction
Wnt Proteins / physiology*
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/DCSTAMP protein, human; 0/Membrane Proteins; 0/NFATC Transcription Factors; 0/RANK Ligand; 0/Wnt Proteins; 81627-83-0/Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  L-arginine, NO and asymmetrical dimethylarginine in hypertension and type 2 diabetes.
Next Document:  Angiogenic signaling aberrantly induced by tumor hypoxia.