Document Detail


Regulatory function of delta6 desaturate -- key enzyme of polyunsaturated fatty acid synthesis.
MedLine Citation:
PMID:  200115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The delta6 desaturation of unsaturated acyl-CoA is the first reaction involved in the normal biosynthesis of all polyunsaturated fatty acids families in animal microsomes. Due to this key position it can regulate the biosynthesis of the fatty acids of the series. The reaction is modified by competition with substrates and products, ATP, and acyl-CoA acceptors. Dietary glucose and fructose inhibit the enzyme whereas protein diets and essential fatty acid deficient diets enhance the reaction independently of hormonal effects. The enzyme is sensitive to hormones concentration. Insulin enhance the reaction but the effect is eliminated by protein synthesis inhibition. Hyperglucemic hormones as glucagon, and epinephrine depress the activity of the delta6 desaturase by reactions triggers by an increase of cAMP concentration. The lateral relation of linoleic or alpha-linolenic microsomal elongation is insensitive to insulin, glucagon, epinephrine and protein. All these effects have been proved by either in vivo experiments or cell culture using linoleic or alpha-linolenic acids as substrates.
Authors:
R R Brenner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  83     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1977  
Date Detail:
Created Date:  1977-12-29     Completed Date:  1977-12-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  85-101     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bucladesine / pharmacology
Dietary Fats
Dietary Proteins
Fasting
Fatty Acid Desaturases / metabolism*
Fatty Acids, Essential / deficiency
Glucagon / pharmacology
Insulin / pharmacology
Kinetics
Linoleic Acids / metabolism
Lipids / physiology
Membranes / enzymology
Microsomes, Liver / drug effects,  enzymology*
Rats
Theophylline / pharmacology
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Dietary Proteins; 0/Fatty Acids, Essential; 0/Linoleic Acids; 0/Lipids; 11061-68-0/Insulin; 362-74-3/Bucladesine; 58-55-9/Theophylline; 9007-92-5/Glucagon; EC 1.14.19.-/Fatty Acid Desaturases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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