Document Detail

Regulatory effects of Y4 receptor agonist (BVD-74D) on food intake.
MedLine Citation:
PMID:  20600429     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to clarify the role of a novel agonist with high selectivity and affinity for Y4 receptors in the regulation of food intake. The Y4 receptor agonist BVD-74D was administered to C57BL/6J mice that were fed with a normal or high-fat diet, and to fatty liver Shionogi (FLS)-ob/ob mice; the food intake, water intake, and body weight gain were measured in these mice. In the mice fed with a normal diet, the cumulative food intake significantly decreased at 20 min and 1 h after the administration of 1 mg/kg of BVD-74D and at 1, 2, 4, 8, and 24 h after the administration of 10 mg/kg of BVD-74D. Moreover, the cumulative water intake and body weight gain significantly decreased in these mice. Among the mice that were fed with a high-fat diet, the cumulative food intake and water intake significantly decreased 1, 2, and 4 h after BVD-74D (10 mg/kg) administration. Furthermore, the cumulative food intake significantly decreased 2 and 4 h after BVD-74D (10 mg/kg) administration in the FLS-ob/ob mice. Thus, we propose that the novel Y4 receptor agonist BVD-74D has suppressive effects on food intake, water intake, and weight gain in normal mice fed with normal diets and on food intake in normal mice fed with high-fat diets and in FLS-ob/ob mice. These findings indicate that the Y4 receptor and its agonist would be promising targets for obesity.
Jiang-Bo Li; Akihiro Asakawa; Mutsumi Terashi; KaiChun Cheng; Huhe Chaolu; Takahiro Zoshiki; Miharu Ushikai; Sulaiman Sheriff; Ambikaipakan Balasubramaniam; Akio Inui
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-06-22
Journal Detail:
Title:  Peptides     Volume:  31     ISSN:  1873-5169     ISO Abbreviation:  Peptides     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1706-10     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Division of Psychosomatic Internal Medicine, Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
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MeSH Terms
Anti-Obesity Agents / adverse effects,  therapeutic use*
Anxiety / chemically induced
Appetite Depressants / adverse effects,  therapeutic use
Appetite Regulation / drug effects*
Behavior, Animal / drug effects
Dietary Fats / administration & dosage
Dose-Response Relationship, Drug
Drinking / drug effects
Fatty Liver / drug therapy
Mice, Inbred C57BL
Mice, Obese
Obesity / drug therapy*
Peptides / adverse effects,  therapeutic use*
Receptors, Neuropeptide Y / agonists*
Time Factors
Weight Gain / drug effects
Reg. No./Substance:
0/Anti-Obesity Agents; 0/Appetite Depressants; 0/BVD-74D peptide; 0/Dietary Fats; 0/Peptides; 0/Receptors, Neuropeptide Y; 0/neuropeptide Y4 receptor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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