Document Detail

Regulatory effect of calcium on 3H-dopamine binding to guinea-pig heart membrane preparations.
MedLine Citation:
PMID:  3937163     Owner:  NLM     Status:  MEDLINE    
The effects of various cations on the specific binding of dopamine to its recognition sites are described using guinea-pig heart membranes as a substrate. Only CaCl2 provoked a dose-dependent facilitatory effect, while KCl, NaCl and MgCl2 acted in the opposite sense. Moreover, Na2EDTA also had an inhibitory effect on dopamine binding and completely prevented the facilitatory action of CaCl2 on 3H-dopamine binding. This effect is partially counteracted by trifluoperazine but unaffected by verapamil. We can conclude from this that calcium seems to be essential to optimizing 3H-dopamine binding to cardiac membrane preparations.
M Sandrini; A Benelli; M Baraldi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Pharmacological research communications     Volume:  17     ISSN:  0031-6989     ISO Abbreviation:  Pharmacol Res Commun     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1986-03-07     Completed Date:  1986-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0236354     Medline TA:  Pharmacol Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  991-1003     Citation Subset:  IM    
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MeSH Terms
Calcium / physiology*
Calcium Chloride / pharmacology
Dopamine / metabolism*
Edetic Acid / pharmacology
Guinea Pigs
Membranes / metabolism
Myocardium / metabolism*
Potassium / pharmacology
Trifluoperazine / pharmacology
Verapamil / pharmacology
Reg. No./Substance:
10043-52-4/Calcium Chloride; 117-89-5/Trifluoperazine; 52-53-9/Verapamil; 60-00-4/Edetic Acid; 7440-09-7/Potassium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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