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Regulatory characteristics of the Vibrio vulnificus rtxHCA operon encoding a MARTX toxin.
MedLine Citation:
PMID:  22996810     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Vibrio vulnificus MARTX encoded by rtxA, an open reading frame of the rtxHCA operon, is essential for virulence in vitro and in mice. In this study, a primer extension analysis revealed that transcription of the rtxHCA operon begins at a single site, and is under the direction of a single promoter, P( rtxHCA ). P( rtxHCA ) activity appeared at the beginning of growth and reached a maximum in mid-exponential phase. P( rtxHCA ) activity was induced by exposure to INT-407 cells, and the membrane fraction of INT-407 cells was the most effective for the induction.
Authors:
Jinseo Park; Seung Min Kim; Hee Gon Jeong; Sang Ho Choi
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-21
Journal Detail:
Title:  Journal of microbiology (Seoul, Korea)     Volume:  -     ISSN:  1976-3794     ISO Abbreviation:  J. Microbiol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9703165     Medline TA:  J Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
National Research Laboratory of Molecular Microbiology and Toxicology, Department of Agricultural Biotechnology, Center for Food Safety and Toxicology, Seoul National University, Seoul, 151-921, Republic of Korea.
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