Document Detail


Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation.
MedLine Citation:
PMID:  16903919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The gastrointestinal (GI) tract is the main interface where the body encounters exogenous antigens. It is crucial that the local response here is tightly regulated to avoid an immune reaction against dietary antigens and commensal flora while still mounting an efficient defense against pathogens. Faults in establishing intestinal tolerance can lead to disease, inducing local and often also systemic inflammation. Studies in human as well as in animal models suggest a role for regulatory T cells (Tregs) in maintaining intestinal homeostasis. Transfer of Tregs can not only prevent the development of colitis in animal models but also cure established disease, acting both systemically and at the site of inflammation. In this review, we discuss the major regulatory pathways, including transforming growth factor-beta (TGF-beta), interleukin-10 (IL-10), and cytotoxic T-lymphocyte antigen-4 (CTLA-4), and their role in Treg-mediated control of systemic and mucosal responses. In addition, we give an overview of the known mechanisms of lymphocyte migration to the intestine and discuss how CD103 expression can influence the balance between regulatory and effector T cells. Further understanding of the factors that control the activity of Tregs in different immune compartments may facilitate the design of strategies to target regulation in a tissue-specific way.
Authors:
Ana Izcue; Janine L Coombes; Fiona Powrie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  212     ISSN:  0105-2896     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-14     Completed Date:  2006-10-05     Revised Date:  2007-08-13    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  256-71     Citation Subset:  IM    
Affiliation:
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD / metabolism
Antigens, Differentiation / metabolism
Cell Movement
Colitis / immunology*,  prevention & control,  therapy*
Humans
Immunosuppression*
Integrin alpha Chains / metabolism
Interleukin-10 / metabolism
Intestinal Mucosa / immunology*
T-Lymphocytes, Regulatory / immunology*,  transplantation
Transforming Growth Factor beta / metabolism
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation; 0/Integrin alpha Chains; 0/Transforming Growth Factor beta; 0/alpha E integrins; 0/cytotoxic T-lymphocyte antigen 4; 130068-27-8/Interleukin-10

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