| Regulatory T cells and the quest for transplant tolerance. | |
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MedLine Citation:
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PMID: 21276408 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Many regulatory cell types exist in the immune system; they contribute to immune tolerance and immune homeostasis via different mechanisms. Therapeutic manipulation of such cell types for the induction of transplant tolerance has attracted tremendous attention. However, studies in this area have uncovered unexpected challenges, and translation of regulatory T cells toward clinical utilities is fraught with difficulties. In this review, we provide a broad overview on recent progresses in the study of regulatory T cells, highlighting the complexities of regulatory cell types and the unanticipated challenges. We also discuss the opportunities and emerging approaches in harnessing the potency of regulatory T cells in clinical transplantation. |
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Authors:
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Silvia Spoerl; Xian C Li |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Discovery medicine Volume: 11 ISSN: 1944-7930 ISO Abbreviation: Discov Med Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101250006 Medline TA: Discov Med Country: United States |
Other Details:
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Languages: eng Pagination: 25-34 Citation Subset: IM |
Affiliation:
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The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA. xli@bidmc.harvard.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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