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Regulatory T cells and the quest for transplant tolerance.
MedLine Citation:
PMID:  21276408     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Many regulatory cell types exist in the immune system; they contribute to immune tolerance and immune homeostasis via different mechanisms. Therapeutic manipulation of such cell types for the induction of transplant tolerance has attracted tremendous attention. However, studies in this area have uncovered unexpected challenges, and translation of regulatory T cells toward clinical utilities is fraught with difficulties. In this review, we provide a broad overview on recent progresses in the study of regulatory T cells, highlighting the complexities of regulatory cell types and the unanticipated challenges. We also discuss the opportunities and emerging approaches in harnessing the potency of regulatory T cells in clinical transplantation.
Authors:
Silvia Spoerl; Xian C Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Discovery medicine     Volume:  11     ISSN:  1944-7930     ISO Abbreviation:  Discov Med     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101250006     Medline TA:  Discov Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-34     Citation Subset:  IM    
Affiliation:
The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA. xli@bidmc.harvard.edu.
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