Document Detail


Regulatory T cells in psoriasis.
MedLine Citation:
PMID:  16329653     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Psoriasis is a chronic autoimmune disease in which T lymphocytes are thought to be central in the pathogenesis. Recently, a T cell subset population was identified, whose role is to suppress inflammatory responses triggered by T effector cells. T cells in this new population are referred to as T regulatory cells. We studied their number and activity in psoriatic lesions and found that they are both numerically and functionally deficient in their ability to suppress the abnormally persistent psoriatic immune response. This deficiency may shed more light on the complex pathophysiology of psoriasis.
Authors:
M H Kagen; T S McCormick; K D Cooper
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Ernst Schering Research Foundation workshop     Volume:  -     ISSN:  0947-6075     ISO Abbreviation:  Ernst Schering Res. Found. Workshop     Publication Date:  2006  
Date Detail:
Created Date:  2005-12-06     Completed Date:  2006-02-10     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  9422786     Medline TA:  Ernst Schering Res Found Workshop     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  193-209     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Autoimmune Diseases / immunology
Humans
Lymphocyte Activation
Psoriasis / drug therapy,  immunology*,  pathology
Recombinant Fusion Proteins / immunology,  therapeutic use
Skin / cytology,  immunology
T-Lymphocyte Subsets / immunology*
T-Lymphocytes, Regulatory / immunology*
Grant Support
ID/Acronym/Agency:
R01 AR051498/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Recombinant Fusion Proteins; ELK3V90G6C/alefacept

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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